OP 1Evaluation of total HIV-DNA and residual viremia in HIV-1 infected patients who continue a two-drug regimen with dolutegravir plus one reverse transcriptase inhibitor or switch to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide enrolled in the Be-OnE Study

M.M. Santoro1, N. Gianotti2, L. Galli2, R. Scutari1, C. Alteri3, A. Poli2, L. Piermatteo1, A. Bigoloni2, C.F. Perno3, A. Lazzarin2, F. Ceccherini-Silberstein1, A. Castagna2,4

1University of Rome “Tor Vergata”, Rome, 2Infectious Diseases, IRCCS San Raffaele, Milan, 3University of Milan, Milan, 4Vita-Salute San Raffaele University, Milan

OP 2Durability and liver safety of InSTI-based regimens in HIV-infected patients with advanced liver fibrosis or cirrhosis: data from the ODOACRE cohort

A. Lanari1, B. Rossetti2, A. Ciccullo3,4, V. Borghi5, A. Dusina3,4, C. Cassol1, G. Cuomo5, A. D’Angelillo3,4, F. Montagnani1, C. Mussini5, S. Di Giambenedetto3,4, M. Fabbiani2

1UOC Malattie Infettive e Tropicali, Dipartimento di Biotecnologie Mediche, Università di Siena, Siena, 2UOC Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Senese, Siena, 3Università Cattolica del Sacro Cuore, Dipartimento di Sicurezza e Bioetica Sezione Malattie Infettive, Rome, 4UOC Malattie Infettive, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, 5Clinica Malattie Infettive e Tropicali, Azienda Ospedaliero Universitaria di Modena, Modena

OP 3Prevalence of transmitted resistance mutations to rilpivirine and doravirine in treatment-naive patients in a large clinical and resistance database

F. Lombardi1, V. Costabile2, A. Lai3, L. Taramasso4, M. Siano3, B. Bruzzone5, V. Micheli6, A. Callegaro7, E. Paolini8, F. Maggiolo9, G. Colao10, P. Meraviglia6, P. Bagnarelli11, A. Shallvari12, S. Rusconi3

1Università Cattolica del Sacro Cuore, Dipartimento di Sicurezza e Bioetica Sezione Malattie Infettive, Roma, Italy, 2Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy, 3Infectious Disease Unit, DIBIC Luigi Sacco, University of Milan, Milan, Italy, 4Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, 5Hygiene Unit, IRCCSAOU San Martino-IST, Genoa, Italy, 6Laboratorio Microbiologia Ospedale L. Sacco ,Seconda Divisione Malattie Infettive, Milan, Italy, 7Department of Laboratory Medicine, ASST Papa Giovanni XXIII, Bergamo, Italy, 8Servizio Immunoematologia e Medcina Trasfusionale, Cremona Hospital, Cremona, Italy, 9Division of Infectious Diseases, ASST Papa Giovanni XXIII, Bergamo, Italy, 10Laboratory of Virology, Careggi Hospital, Firenze, Italy, 11Virology Unit, Azienda Ospedaliera Universitaria Ospedali Riuniti di Ancona, Ancona, Italy, 12IPRO - InformaPRO S.r.l., Rome

OP 4Efficacy and tolerability of bictegravir/ tenofovir alafenamide/ emtricitabine as a switch strategy in a cohort of antiretroviral therapy treatment-experienced HIV-1-infected patients

F. Lagi1, A. Botta1, M. Trotta2, B. Borchi2, P. Rogasi2, P. Nizzoli3, A. Bartoloni1,2, G. Sterrantino1

1Department of Experimental and Clinical Medicine, University of Florence, Florence Italy, 2Infectious and Tropical Diseases Unit, Careggi University and Hospital, Florence, Italy, 3Department of Pharmaceuticals, USL Toscana Centro, Careggi- Pharmacy, Florence, Italy

OP 5Viral rebound in pts with suppressed HIV-RNA on a 2 or 3-drug regimen: a comparison

A. Borghetti1, A. Giacomelli2,3, M. Colafigli4, A. Lanari5, L. Celani6, V. Borghi7, A. Ciccullo8, S. Rusconi2,3, A. Latini4, F. Lombardi8, L. Oreni2,3, C. Mussini7, S. Di Giambenedetto1,8

1Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma Italia, UOC malattie infettive, 2III Infectious Disease Unit, ASST-FBF-Sacco, Milan, Italy, 3Department of Biomedical and Clinical Sciences DIBIC L. Sacco, University of Milan, Milan, Italy, 4Infectious Dermatology and Allergology, IFO San Gallicano, Rome, Italy, 5Hospital Department of Specialized and Internal Medicine, Infectious Diseases Unit, University Hospital of Siena, Siena, Italy, 6Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy, 7Clinica delle Malattie Infettive e Tropicali dell'Università di Modena e Reggio Emilia, Modena, Italy, 8Università Cattolica del Sacro Cuore, Roma Italia, Istituto di Clinica Malattie Infettive

OP 6Optically traceable PLGA Nanoparticles improve the ability of darunavir to cross the blood brain barrier and inhibit MMP-9. Implications for the Treatment of HIV-Associated Neurological Disorders

S. Milella1, N. Depalo2, A. Panniello2, F. Rizzi2, V. Laquintana3, N. Denora3, C.M. Mastroianni4, G.M. Liuzzi1, M.L. Curri5, T. Latronico1

1Dipartimento di Bioscienze, Biotecnologie e Biofarmaceutica, Università degli Studi di Bari Aldo Moro, Italy, 2Consiglio Nazionale delle Ricerche, Istituto per i Processi Chimico-Fisici, Bari, Italy, 3Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Bari, Italy, 4Dipartimento di Sanità Pubblica e Malattie Infettive della Facoltà di Farmacia e Medicina, Università degli Studi di Roma "La Sapienza", Roma, Italy, 5Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Bari, Italy

OP 7Effectiveness and long-term durability of rilpivirine-based single tablet regimens in a large cohort of HIV-infected patients. A preliminary analysis

L. Magnasco1, R. Pincino1, G. Sarteschi1, S. Lo Caputo2, S. Bruno2, S. Ferrara2, F. Briano1, D. Malucelli3, S. Beltramini4, E. Sasso4, A. Di Biagio1

1U.O. Clinica Malattie Infettive, University of Genoa (DISSAL) and Ospedale Policlinico San Martino-IRCCS per L'Oncologia, Genova, 2U.O. Clinica Malattie Infettive, University of Foggia, 3SANTALUCIA PHARMA APPS©, Località Gragnanino, Gragnano Trebbiense, 4U.O. Farmacia, Ospedale Policlinico San Martino-IRCCS per l'Oncologia, Genoa

OP 8Increase in body weight after a year of INI-exposure in a multicenter italian cohort

A. Ciccullo1, G. Baldin1,2, G. Sterrantino3, M. Colafigli4, G. d’Ettorre5, A. Lanari6, G. Greco7, A. De Vito8, L. Celani5, A. Giacomelli9, F. Lagi3, S. Rusconi9, S. Di Giambenedetto1,10, G. Madeddu8

1Section of Infectious Diseases, Department of Safety and Bioethics, Catholic University of the Sacred Heart, Rome, Italy, 2Mater Olbia Hospital, Olbia, Italy, 3Infectious Diseases Unit, Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy, 4Infectious Dermatology and Allergology Unit, S. Gallicano Institute IRCCS, Rome, Italy, 5Department of Public Health and Infectious Diseases, Azienda Policlinico Umberto I, Rome, Italy, 6Infectious Diseases Unit, Siena University Hospital, Siena, Italy, 7Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, "Magna Graecia" University, Catanzaro, Italy, 8Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy, 9Infectious Diseases Unit, DIBIC Luigi Sacco, University of Milan, Milan, Italy, 10Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italia

OP 9Treatment outcome among HIV-1 infected patients who started first-line ART pending GRT results from 2015 to 2018

D.F. Bavaro1, G. Pasculli2,3, A. De Vito4, R. Lattanzio1, F. Saladini5, L. Magnasco6, R. Yagai Bouba7, R. Pincino6, R. Corsini8, S. Arima9, F. Incardona3,10, B. Rossetti11, A. Bezenchek10, V. Borghi12, A. Di Biagio6

1Department of Biomedical Sciences and Human Oncology, Clinic of Infectious Diseases, University of Bari, Bari, Italy, 2Department of Computer, Control, and Management Engineering Antonio Ruberti (DIAG), La Sapienza University, Rome, Italy, 3EuResist Network, ROme, Italy, 4Unit of Infectious Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy, 5Department of Medical Biotechnologies, University of Siena, Italy, 6Department of Health’s Sciences, University of Genoa, Genoa, Italy, 7Department of experimental medicine, University of Rome “Tor Vergata”, Rome, Italy. 8Infectious Diseases Unit, Azienda USL-IRCCS di Reggio Emilia, 9Department of Methods and Model for Economy Territory and Finance, University of Rome “La Sapienza”, Rome, Italy, 10INFORMAPRO Srl, Rome, Italy, 11Infectious Diseases Unit, Azienda Ospedaliero-Universitaria Senese, Siena, Italy, 12Clinic of Infectious Disease, Azienda Ospedaliero Universitaria di Modena

OP 10Retrospective analysis of reasons and characteristics of switches in a cohort of women affected by HIV infection referring to D. Cotugno Hospital, Naples, period 2017-2019

F.M. Fusco1, V. Rizzo2, M.A. Carleo2, S. Mascolo2, R. Viglietti1, M. D’Abbraccio2, V. Esposito2

1UOC Infezioni Sistemiche e dell’Immunodepresso, P.O. “D. Cotugno”, Azienda Ospedaliera dei Colli, Naples, Italy, 2UOC Immunodeficienze e Malattie Infettive di Genere, P.O. “D. Cotugno”, Azienda Ospedaliera dei Colli, Naples, Italy

OP 11Assessing the feasibility of 2-drug regimens as switch strategies in a multicenter cohort

A. Borghetti1,2, A. Ciccullo2, M. Colafigli3, E. Anzalone4, A. Pennica5, A. Dusina2, D. Farinacci2, A. Latini3, F. Di Sora6, S. Di Giambenedetto1,2

1Fondazione Policlinico Universitario Agostino Gemelli IRCCS, UOC Malattie Infettive, Roma, Italy, 2Dipartimento di Sicurezza e Bioetica, Sezione di Malattie Infettive, Università Cattolica del Sacro Cuore, Roma, Italy, 3Dermatologia Infettivologica ed Allergologica, Istituto Dermatologico San Gallicano IRCCS, Roma, Italy, 4UOSD AIDS, Presidio Ospedaliero Frosinone, Italy, 5Facoltà di Medicina e Psicologia "La Sapienza", Presidio Ospedaliero S. Andrea, Roma, Italy, 6Dipartimento di Malattie Infettive, Ospedale S. Giovanni Addolorata, Roma, Italy

OP 12Risk of failure in dual vs triple therapy in naïve HIV-patients: a meta-analysis

A. Russo, M. Pisaturo, L. Onorato, S. Martini, S. Simona, P. Maggi, N. Coppola

University of Campania Luigi Vanvitelli, Naples, Italy

OP 13DAA treatment fails to restore the inflammatory profile both in HCV/HIV and in HCV infected patients

V. Bordoni, A. Vergori, S. Notari, C. Gruber, C. Montaldo, M. Tripodi, E. Cimini, R. Casetti, G. Grassi, A. Sacchi, E. Tartaglia, R. Lionetti, M. Bibas, G. D’Offizi, E. Grilli, A. Antinori, C. Agrati

National Institute for Infectious Diseases L Spallanzani - IRCCS - Rome

OP 14Sterol metabolism modulates susceptibility to HIV-1 Infection

I. Saulle1, S.V. Ibba1, C. Vittori1, C. Fenizia1, V. Mercurio1, F. Vichi2, S. Lo Caputo3, D. Trabattoni1, M. Clerici1,4, M. Biasin1

1Department of Biomedical and Clinical Sciences “L. Sacco”, University of Milan, Milan, Italy, 2S. Maria Annunziata Hospital, Florence, Italy, 3Clinica delle Malattie Infettive dell’Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, 4Don C. Gnocchi Foundation ONLUS, IRCCS, Milan, Italy

OP 15Different amounts of activated or exhausted effector memory T cells among differentiated CD4+ or CD8+ T lymphocytes during primary, acute HIV infection

D. Lo Tartaro1, A. Camiro-Zúñiga2, S. Perez-Patrigeon2, A. Paolini1, M. Nasi1, C. Mussini1, A. Cossarizza1, S. De Biasi1

1Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy, 2National Institute for Medical Sciences and Nutrition "Salvador Zubirán", Tlalpan, Mexico City, Mexico

OP 16HIV+ patients: modulating effects of antiretroviral therapy on cytokines' profile and microbiota composition

G. Nannini1, E. Russo1, V. Di Pilato2, M. Coppi1, F. Ricci3, E. Niccolai1, S. Tekle Kiros4, S. Baldi1, A. Bartoloni4,5, G.M. Rossolini1,6, A. Amedei1

1Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy, 2Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy, 3Department of Biomedical, Experimental and Clinical Sciences “Mario Serio” University of Florence, Florence, Italy, 4Infectious Disease Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 5Infectious and Tropical Disease Unit, Azienda Ospedaliero - Universitaria Careggi, Florence, Italy, 6Department of Experimental and Clinical Medicine, University of Florence, Italy; Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy

OP 17Association between subclinical atherosclerosis and IFN-I response in HIV-1 infected patients

G. De Girolamo1, L. Santinelli1, C. Borrazzo1, C. Pinacchio1, G.P. Innocenti1, P. Vassalini1, E. Nelson Cavallari1, M,. Statzu2, F. Frasca2, M. Scordio2, M. Mancone3, G. Antonelli2, G. d’Ettorre1, C. Scagnolari2

1Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy, 2Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Rome, Italy, 3Department of Cardiovascular, Respiratory, Nephrologic and Geriatric Sciences, Sapienza University of Rome, Rome, Italy

OP 18p53/mir34a/SIRT1 loop and immune reconstitution relationship during chronic HIV infection

V. Bordoni, E. Tartaglia, A.Sacchi, A. Vergori, R. Gagliardini, A. Antinori, C. Agrati

National Institute for Infectious Diseases “L. Spallanzani” IRCCS

OP 19Lower Immune Activation in Perinatally than in Horizontally HIV-Infected Adults

L. Taramasso1,2, D. Fenoglio3,4, A. Parodi5, F. Kalli3, A. Bandera1,2, C. Dentone6, T. Altosole3, M. Berruti6, S. Mora7, M. Giacomini3,7, G. Filaci3,5, A. Di Biagio6

1Infectious Diseases Unit, Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy, 2MultidisciplinAry ResearCh in Health Science (MACH), Milan, Italy, 3Centre of Excellence for Biomedical Research (CEBR), University of Genova, Genoa, Italy, 4Department of Internal Medicine, University of Genoa- IRCCS Ospedale Policlinico San Martino, Genoa, Italy, 5Biotherapy Unit, IRCCS Policlinico San Martino Hospital, Genoa Italy, 6Department of Health Science (DISSAL), University of Genova and Infectious Disease Clinic, IRCCS Policlinico San Martino Hospital, Genoa, Italy, 7Department of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, Genoa, Italy

OP 20Microbiota Composition in HIV-Positive and HIV-Exposed Uninfected Pediatric Subjects

E. Merlini1, M. Ficara2, E.S. Cannizzo1, F. Ferrari2, C. Tincati1, L. Dotta3, C. Tagliabue4, A. Diana5, V. Camelli6, L. Iughetti2,7, A. d'Arminio Monforte1, M. Cellini2, G. Marchetti1 for the MIRROR Study Group

1Clinic of Infectious Diseases, Dept Health Sciences, University of Milan, ASST Santi Paolo e Carlo, Milan, Italy, 2Division of Paediatric Oncology-Haematology, Policlinico Hospital, Modena, Italy, 3Clinica Pediatrica and "A. Nocivelli" Institute for Molecular Medicine, Department of Clinical and Experimental Sciences, University of Brescia, Spedali Civili Hospital, Brescia, 4Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy, 5Department of Translational Medical Science, Section of Pediatrics, University Federico II, Naples, Italy, 6Dept of Sciences of Public Health and Pediatrics, University of Turin, Italy, 7Pediatric Unit, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy

OP 21Switching to integrase inhibitors is not linked to weight increase in young adults and adolescents perinatally infected with HIV, results from a 10-years observational study

L. Taramasso1,2, A. Di Biagio3, F. Bovis4, F. Forlanini5, E. Albani5, R. Papaioannu3, V. Giacomet5

1Infectious Diseases Unit, Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy, 2MultidisciplinAry ResearCh in Health Science (MACH), Milan, Italy, 3Infectious Diseases Clinic, Department of Health Sciences (DiSSal), University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, 4Biostatistics Unit, Department of Health Sciences (DiSSal), University of Genoa, Italy, 5Clinic of Paediatrics, ASST Fatebenefratelli-Sacco, Milan, Italy

OP 22An atypical case of HIV-1 elite controller: 15 years of follow up

C. Fimiani1, F. Falasca2, C. Cerboni2, H. Stabile2, C. Scagnolari2, O. Turriziani2

1Department of Internal Medicine and Infectious Disease, University Hospital Policlinico Umberto I, Rome, 2Department of Molecular Medicine, Sapienza University of Rome

OP 23Newly diagnosed HIV infected patients in Brescia, Northern Italy: epidemiological and clinical characteristics and possible targets of prevention and early diagnosis campaign

I. Izzo, G. Zuglian, C. Carriero, A. Celotti, E. Focà, M.A. Forleo, I. El Hamad, P. Nasta, M.C. Pezzoli, E. Quiros-Roldan, F. Castelli

University Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy

OP 24Rosuvastatin decreases serum inflammatory markers and slows atherosclerosis progression rate in HIV-infected patients with metabolic syndrome

L. Calza, V. Colangeli, M. Borderi, D. Testi, A. Amedeo, M.A. Di Bari, C. Fulgaro, P. Viale

Department of Medical and Surgical Sciences, Unit of Infectious Diseases, S.Orsola-Malpighi Hospital, University of Bologna

OP 25Durability of InSTI-based regimen in geriatric people living with HIV. Data from the Italian Multicenter GEPPO Cohort

E. Focà1, A. Calcagno2, S. Calza3, S. Renzetti3, A. Riva4, G.V. De Socio5, S. Piconi6, G. Orofino7, A. Chiesa1, G. Madeddu8, A. Cattelan9, S. Nozza10, J. Milic11, B.M. Celesia12, F. Castelli1, G. Di Perri2, G. Guaraldi11

1Division of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital,Brescia, Italy, 2Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, Italy, 3Unit of Biostatistics and Biomathematics & Unit of Bioinformatics, Department of Molecular and Translational Medicine, Università degli Studi di Brescia – Italy, 43rd Division of Infectious Diseases, University of Milano, Ospedale L. Sacco, Milano, Italy, 5Department of Infectious Diseases, Azienda Ospedaliero-Universitaria di Perugia, Perugia, Italy, 61st Division of Infectious Diseases Unit, University of Milano, Ospedale L. Sacco, Milano, Italy, 7Unit of Infectious Diseases, 'Divisione A', Ospedale Amedeo di Savoia, ASLTO2, Torino, Italy, 8Infectious and Tropical Diseases Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy, 9Unit of Infectious Diseases, Department of Internal Medicine, Azienda Ospedaliero-Universitaria di Padova, Padova, Italy, 10Department of Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy, 11University of Modena and Reggio Emilia, Department of Mother, Child and Adult Medicine and Surgical Science, Infectious Disease Clinic, Modena, Italy, 12Department of Clinical and Molecular Biomedicine, Division of Infectious Diseases, University of Catania, ARNAS Garibaldi, Catania, Italy

OP 26Weight gain and body composition changes in people living with HIV treated with Integrase Strand Transfer Inhibitors: a longitudinal assessment with Bioimpedance Vectorial Analysis

M. Poliseno1, D.F. Bavaro1, P. Laghetti1, G. De Vita, N. de Gennaro1, S. Lo Caputo2, L. Monno1, G. Angarano1, A. Saracino1

1Department of Biomedical Sciences and Human Oncology, Clinic of Infectious Diseases, University of Bari Medical School, Bari, Italy, 2Clinic of Infectious Diseases University of Foggia, Foggia, Italy

OP 27Transmitted drug resistance in newly diagnosed HIV-1-infected patients in a large teaching hospital of the Northern Italy

L. Calza2, M. Tamburello1, M. Borderi2, V. Colangeli2, D. Testi2, A. Amedeo2, M.C. Re1, I. Bon1

1Unit of Microbiology, University of Bologna (Italy), 2Unit of Infectious Diseases, University of Bologna (Italy)

OP 28Same day treatment and rapid antiretroviral therapy introduction in a cohort of unselected newly-diagnosed HIV-positive individuals

G. Lapadula, M. Rossi, P. Vitiello, N. Squillace, A. Soria, P. Columpsi, F. Sabbatini, E. Colella, V. Cogliandro, A. Spolti, I. Beretta, A. Gambaro, G.M. Migliorino

Clinic of Infectious Diseases, “San Gerardo” Hospital, ASST-Monza, University of Milan-Bicocca, Italy

OP 29Changes in homeostatic model assessment for insulin resistance (HOMA-IR) index in treated HIV-1 infected people on virological suppression

C. Muccini1, L. Galli2, A. Poli2, S. Bossolasco2, P. Cinque2, L. Fumagalli2, D. Canetti2, H. Hasson2, M. Ranzenigo1, M. Chiurlo1, A. Lazzarin2, A. Castagna1,2

1Vita-Salute San Raffaele University, Milan, Italy, 2Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy

OP 30A descriptive analysis on dual regimens' discontinuations in a multicentre Italian cohort

D. Farinacci1, A. Ciccullo1, A. Dusina1, A. D’Angelillo1, D. Moschese1, A. Borghetti2, V. Borghi3, C. Mussini3, S. Di Giambenedetto1,2

1Istituto di Malattie Infettive, Università Cattolica del Sacro Cuore, Roma, Italy, 2Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy, 3Azienda Ospedaliero Universitaria di Modena, Clinica Malattie Infettive e Tropicali, Modena, Italy

OP 31Virological response and resistance profile in highly treatment-experienced HIV-1 infected patients switching to dolutegravir plus boosted-darunavir in clinical practice

D. Armenia1,2, L. Fabeni3, R. Gagliardini4, V. Borghi5, G. Berno3, A. Vergori4, S. Cicalini4, C. Mussini5, A. Antinori4, F. Ceccherini-Silberstein1, C.F. Perno3, M.M. Santoro1

1Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy, 2Saint Camillus International University of Health Sciences, Rome, Italy, 3Laboratory of Virology, INMI "Lazzaro Spallanzani"-IRCCS, Rome, Italy, 4Clinical Department, INMI "Lazzaro Spallanzani"-IRCCS, Rome, Italy, 5Clinic of Infectious Diseases, University Hospital, University of Modena and Reggio Emilia, Modena, Italy

OP 32Does rapid initiation of ART at HIV diagnosis impact on virological response and retention in care? A single center experience (Brescia, Northern Italy)

A. Comelli, N. Gregori, A. Celotti, S. Renzetti, S. Calza, I. Izzo, C. Pezzoli, I. El Hamad, P. Nasta, M. Properzi, A. Chiesa, M. Degli Antoni, G. Faletti, B. Fumarola, E. Quiros-Roldan, F. Castelli, E. Focà

University Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy

OP 33Efficacy and durability of dolutegravir- or darunavir-based regimens in ART-naïve AIDS- or late-presenter patients

M. Masini1, B. Rossetti2, A. Ciccullo3,4, V. Borghi5, F. Lagi6, A. Capetti7, M. Colafigli8, D. Moschese3,4, C. Mussini5, G. Sterrantino6, C. Picarelli3,4, F. Montagnani1, S. Di Giambenedetto3,4, M. Fabbiani2

1UOC Malattie Infettive e Tropicali, Dipartimento di Biotecnologie Mediche, Università di Siena, Siena, Italy, 2UOC Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Senese, Siena, Italy, 3Università Cattolica del Sacro Cuore, Dipartimento di Sicurezza e Bioetica Sezione Malattie Infettive, Rome, Italy, 4UOC Malattie Infettive, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, 5Azienda Ospedaliero Universitaria di Modena, Clinica Malattie Infettive e Tropicali, Modena, Italy, 6Department of Experimental and Clinical Medicine, University of Florence, Florence Italy, 7Divisione di Malattie Infettive, Dipartimento di Malattie Infettive, Ospedale Universitario Luigi Sacco, Milano, Italy, 8Unità di Dermatologia Infettiva e Allergologia, Istituto S. Gallicano IRCCS, Roma, Italy

OP 34Efficacy Safety and Tolerability of the switch from efavirenz/emtricitabine/tenofovir disoproxil on alternate days or continuous treatment to bictegravir/emtricitabine/tenofovir alafenamide in virologically suppressed HIV+ (EBONY Study)

M. Camici, A. Mondi, F. De Zottis, G. Passavanti, E. Grilli, A. Vergori, R. Gagliardini, S. Ottou, M.M. Plazzi, S. Cicalini, A. Antinori, R. Bellagamba

HIV/AIDS Clinical Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy

OP 35Allogenic hematopoietic stem cell transplantation in HIV-positive recipients: a case series

C. Oltolini1, S. Piemontese2, R. Greco2, D. Clerici2, F. Giglio2, L. Galli1, M. Ripa1,3, B. Castiglioni1, C. Tassan Din1, S. Nozza1, C. Corti2, M. Bernardi2, J. Peccatori2, P. Scarpellini1, A. Lazzarin1, F. Ciceri2,3, A. Castagna1,3

1Clinic of Infectious Diseases, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy, 2Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Milan, Italy, 3University Vita-Salute San Raffaele, Milan, Italy

OP 36Italian survey on clinicians' approach to Latent Tubercular Infection in people living with HIV

L. Caiazzo1,2, A. Calcagno3, F. Vignale1, M. Pontolillo1,4, A. Brandimarte4, A. Auricchio1,4, K. Falasca1,4, J.Vecchiet1,4

1Clinica di Malattie infettive, Chieti, 2Scuola di specializzazione in Malattie infettive e tropicali, Università politecnica delle Marche, Ancona, 3Unità di Malattie Infettive, Università di Torino, Torino, 4Scuola di specializzazione in Malattie infettive e tropicali, Università D'Annunzio, Chieti

OP 37A poor immunological recovery is associated with non-AIDS-defining cancers in the era of HAART: a case-control study

A. Emiliozzi1,2, A. Ciccullo1, A. Dusina1, D. Moschese1, D. Farinacci1, C. Picarelli1, A. D’Angelillo1, S. Lamonica1, F. Lombardi1, G. Baldin1, A. Borghetti3, M. Fabbiani4, S. Di Giambenedetto1,3

1Università Cattolica del Sacro Cuore, Dipartimento di Sicurezza e Bioetica Sezione Malattie Infettive, Roma, Italy, 2UOC Malattie Infettive e Tropicali, Dipartimento di Biotecnologie Mediche, Università di Siena, Siena, Italy, 3Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma Italia, UOC Malattie Infettive,4UOC Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Senese, Siena, Italy

OP 38HPV infection in HIV+, MSM patients followed at a large HIV Clinic in Northern Italy

E. Asperges, V. Zuccaro, L. Pagnucco, R. Gulminetti, R. Maserati, R. Bruno

Infectious Disease Dept, Foundation IRCCS Policlinico “San Matteo” and University of Pavia

OP 39Risk of multiple primary neoplasms and impact on survival of person living with HIV (PLWH)

V. Mazzotta1, P. Lorenzini1, A. Bandera2, A. Gori2, L. Sighinolfi3, S. Rusconi4, P. Bonfanti5, A. Cingolani6, G. Marchetti7, C. Mussini8, A. d’Arminio Monforte7, A. Antinori1 ICONA FOUNDATION STUDY GROUP

1HIV/AIDS Unit, INMI L. Spallanzani IRCCS, Roma, 2IRCCS Policlinico Ospedale Maggiore, University of Milano, 3Division of Infectious Disease, Hospital of Ferrara, Ferrara, 4ASST L. Sacco Hospital, University of Milano, 5Division of Infectious Disease, ASST Lecco, Lecco, 6Fondazione Policlinico A. Gemelli, Catholic University, Roma, 7ASST Santi Paolo e Carlo, University of Milano, 8Clinic of Infectious Disease, University hospital of Modena, Modena

OP 40Development and standardization of a real time PCR for the quantification of HTLV-1 proviral load

A. Primavera1, A. Bertoldi1, I. Bon1, V. D’Urbano1, M. Tamburello1, L. Calza2, M.C. Re1, G. Gallinella3

1Microbiology Section, Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Italy, 2Clinics of Infectious Diseases, Department of Medical and Surgical Sciences, School of Medicine, University of Bologna, Italy, 3Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

OP 41Is pretreatment HIV-1 integrase resistance increasing? A large Italian centre experience

D. Canetti1,2, L. Galli1, A. Poli1, N. Gianotti1, M. Ripa1,2, S. Nozza1, A. Bigoloni1, M. Guffanti1, L. Fumagalli1, M. Sampaolo1, E. Boeri1, A. Lazzarin1, A. Castagna1,2

1Clinic of Infectious Diseases, IRCCS San Raffaele, Milano, Italy, 2Clinic of Infectious Diseases, Vita-Salute San Raffaele University, Milano, Italy

OP 42Association between low levels of HIV-1 DNA and HLA class I molecules in chronic HIV-1 infection

C. Muccini1, L. Galli2, A. Poli2, A. Bigoloni2, A. Mastrangelo1, E. Bruzzesi1, C. Uberti Foppa2, M. Guffanti2, G. Tambussi2, M. Cernuschi1, A. Lazzarin1, A. Castagna1,2

1Vita-Salute San Raffaele University, Milan, Italy, 2Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy

OP 43Evolving epidemiology of HIV/AIDS in Campania Region, 2008-19: is HIV/AIDS population in Campania different?

F.M. Fusco1, A. Menna2, A. Galano2, L. Anna2, A. Mariniello2, M. De Cenzo2, S. Mascolo3, M. Sardo4, R. Viglietti1, G. Parrella1, O. Tambaro1, V. Iodice1, M.A. Pisaturo1, G. Di Flumeri1, E. Manzillo4, V. Esposito3, A. Chirianni1, V. Sangiovanni1

1UOC Infezioni Sistemiche e dell’Immunodepresso, P.O. “D. Cotugno”, Azienda Ospedaliera dei Colli, Naples, Italy, 2Servizio Ospedalizzazione Domiciliare, P.O. “D. Cotugno”, Azienda Ospedaliera dei Colli, Naples, Italy, 3UOC Immunodeficienze e Malattie Infettive di Genere, P.O. “D. Cotugno”, Azienda Ospedaliera dei Colli, Naples, Italy, 4U.O.C. Immunodeficienze e malattie dell’immigrazione, P.O. “D. Cotugno”, Azienda Ospedaliera dei Colli, Naples, Italy

OP 44Impact of boosted vs unboosted antiretroviral regimen on Dolutegravir plasma and intracellular pharmacokinetics

M. Ferrara, C. Alcantarini, A. Lazzaro, A. Di Stefano, S. Biffi, M. Trunfio, M. Tettoni, V. Avataneo, A. Ianniello, E. De Vivo, A. De Nicolò, A. D’Avolio, A. Calcagno, G.D. Perri, S. Bonora

Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino

OP 45Inflammatory and neurometabolite changes among patients switching away from efavirenz and their correlation with neurotoxicity: results from the sub-study of a randomized controlled trial

I. Baldisserotto1, E. Bresciani1, D.P. Bernasconi1, M. Rossi2, E. Focà3, A. di Biagio4, F. Bai5, F. Castelli3, A. Calcagno6, A. d’Arminio Monforte7, A. Torsello1, G.M. Migliorino2, G. Lapadula2 for the Swear Study Group

1University of Milan-Bicocca, Milan, Italy, 2San Gerardo Hospital, Monza, Italy, 3University of Brescia, Brescia, Italy, 4San Martino Hospital, Genoa, Italy, 5San Paolo Hospital, Milan, Italy, 6University of Turin, Turin, Italy, 7University of Milan, Milan, Italy

OP 46Contribution of INSTI, BMI, physical activity or caloric intake to weight gain in PLWH

G. Guaraldi1, J. Milic1, G. Dolci1, A. Malagoli1, F. Carli1, M. Menozzi1, I. Franconi1, A. Raimondi1, G. Ciusa1, V. Masi1, M. Belli1, S. Guaraldi1, C. Mussini1, T.T. Brown2, J.E. Lake3, K. Erlandson4

1Infectious Disease Unit, University of Modena and Reggio Emilia, Modena, Italy, 2Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, 3David Geffen School of Medicine, University of California, Los Angeles, CA, USA, 4University of Colorado-Anschutz Medical Center, Aurora, Colorado

OP 47Cerebrospinal Fluid CXCL13 as a marker of Intrathecal Immunoglobulin Synthesis and Immune-activation in treatment-naïve People Living with HIV

M. Trunfio1, L. Mighetto2, E. Borgogno1, C. Atzori3, A. Di Stefano1, M. Nigra2, D. Imperiale3, S. Bonora1, G. Di Perri1, A. Calcagno1

1Infectious Diseases unit, Amedeo di Savoia hospital, University of Torino, Torino, Italy, 2Diagnostic Laboratory unit, Maria Vittoria hospital, ASL Città di Torino, Torino, Italy, 3Neurology unit, Maria Vittoria hospital, ASL Città di Torino, Torino, Italy

OP 48Evaluation of the association between cognitive performance and HAND diagnosis with the cognitive reserve in naïve HIV-infected patients

A.C. Brita, A. Vergori, G. Passavanti,P. Lorenzini, S. Cicalini, R. Gagliardini, R. Bellagamba, E. Grilli, A. Mondi, S. Grisetti, V. Mazzotta, F. Baldini, A. Giannetti, A. Antinori, C. Pinnetti

National Institute for Infectious Diseases, IRCCS, L. Spallanzani-HIV/AIDS Unit,Rome,Italy

OP 49Are Low vitamin D plasma levels associated with intrathecal immuneactivation in PLWH?

A. Vergori1, V. Bordoni2, P. Lorenzini1, G. Passavanti1, S. Notari2, V. Mazzotta1, S. Cicalini1, A. Giannetti1, F. Forbici3, C. Agrati2, A. Antinori1 ,C. Pinnetti1

1HIV/AIDS Unit, National Institute for Infectious Diseases L.Spallanzani, IRCCS, 2Cellular immunology and Pharmacology Unit, National Institute for Infectious Diseases L.Spallanzani, IRCCS, 3Virology Unit,National Institute for Infectious Diseases L. Spallanzani, IRCCS

OP 50Gender differences in neurocognitive functions in PLWK

V. Delle Donne1, N. Ciccarelli2, V. Massaroni1, F. Lombardi1, C. Picarelli1, A. Borghetti1, A. Emiliozzi1, A. Dusina1, A. Ciccullo1, D. Moschese1, G. Baldin1,5, D. Farinacci1, S. Di Giambenedetto1,4, M.Fabbiani3

1Università Cattolica del Sacro Cuore, Roma Italia, Istituto di Clinica Malattie Infettive, 2Dipartimento di Psicologia, Università Cattolica di Milano, 3UOC Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Senese, Siena, Italy, 4Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma Italia, UOC malattie infettive, 5Mater Olbia Hospital, Olbia, Italy

OP 51Menopause in aging women living with HIV: changes in bone mineral density and trabecular bone score

D. Morini1, A. Malagoli2, J. Milic2,3, F. Carli2, A. Raimondi2, I. Franconi2, C. Mussini2, V. Rochira4, G. Guaraldi2

1University of Modena and Reggio Emilia, Modena, Italy, 2Modena HIV Metabolic Clinic, University of Modena and Reggio Emilia, Italy, 3Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy, 4Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

OP 52NAFLD phenotype and prevalence across the menopause spectrum in women with HIV

J. Milic1, A. Cervo2, A. Malagoli1, V. Menozzi1, D. Morini1, F. Carli1, A. Raimondi1, M. Menozzi1, I. Franconi1, C. Mussini1, G. Sebastiani3, G. Guaraldi1

1University of Modena and Reggio Emilia, 2Infectious Diseases Unit, PROMISE, University of Palermo, Palermo, Italy, 3Chronic Viral Illness Service, McGill University Health Centre, Montreal, Canada

OP 53Incidence of diabetes in a cohort of PLWH people living with HIV in Perugia

M. Nofri1, E. Schiaroli1, S. Parrettini2, M. Cavallo2, V. Bianconi 3, V.G. De Socio1, R. Calafiore2, D. Francisci1

1Unit of Infectious Diseases, Department of Medicine, University of Perugia, Perugia, Italy, 2Division of Endocrinology and Metabolism, Department of Medicine,University of Perugia, Perugia, Italy, 3Unit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, Italy

OP 54Standard vs higher dose of Rifampicin in patients with tuberculosis: a meta-analysis

V. Gentile1, L. Onorato1, A. Russo1, L. Alessio2, G. DiCaprio2, N. Coppola1

1Department of Mental Health and Public Medicine – Infectious Diseases Unit, University of Campania Luigi Vanvitelli; Napoli, 2Infectious Diseases Unit, Sant' Anna e San Sebastiano Hospital; Caserta

OP 55Rapid Detection of Mycobacterium tuberculosis DNA in pulmonary and extrapulmonary paraffinized samples by ddPCR

M. Antonello1, R. Scutari2, C. Lauricella3, S. Renica1, V. Motta3, S. Torri4, S.M. Veronese3, L.R. Codecasa5, E. Bonoldi3, C. Vismara4, A. Bandera6, E. Mazzola4, A. Gori6, C.F.Perno1,4, C. Alteri1 on behalf of IFALT study group

1Department of Oncology and Hemato-Oncology, University of Milan, Milan, 2Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, 3Department of Pathology, ASST Grande Ospedale Metropolitano Niguarda, Milan, 4Unit of Microbiology, Department of Chemical-clinical and Microbiology Analyses, ASST Grande Ospedale Metropolitano Niguarda, Milan, 5Regional TB Reference Centre, Villa Marelli Institute, ASST Grande Ospedale Metropolitano Niguarda, Milan, 6Infectious Unit, IRCCS Policlinico Maggiore, Milan

OP 56Pharyngeal contamination is a major driver for sexually transmitted infections epidemic in Men who have Sex with Men

R. Rossotti1, C. Baiguera1, C. Vismara2, M. Merli1, A.Nava2, S. Chiappetta1, M.C. Moioli1, D. Fanti2, L.G. Chianura1, D. Motta1, C.F. Perno2,3, M. Puoti1

1Department of Infectious Diseases, ASST Grande Ospedale Metropolitano Niguarda, Milan, 2Chemical-Clinical and Microbiological Analysis, ASST Grande Ospedale Metropolitano Niguarda, Milan, 3Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan

OP 57HCV infection in PWUD: a microelimination intervention in Rome

C. Taibi1, I. Luzzitelli1, A.R. Garbuglia2, L. Rapisarda3, G. Monacelli3, U. Visco Comandini1, R. Lionetti1, E. Girardi4, G. D'Offizi1

1Hepatology and Infectious Disease Department, National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Rome, 2Virology Unit, National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Rome, 3Service for Addictions Department. ASL RM3, Rome, 4Epidemiology Unit, National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, Rome

OP 58Direct-acting antiviral based treatment for HCV-infected persons who inject drugs: a multi-centre real-life study

L. Onorato1, V. Messina1, G. Di Caprio1, A. Russo1, C. Caruso2, V. Rosato3, E. Claar3, V. Iovinella2, N. Coppola4

1Infectious Diseases Unit, AORN Sant’Anna e San Sebastiano, Caserta, Italy, 2Department of Internal Medicine, San Paolo Hospital, Naples, Italy, 3Hepatology Unit, "Villa Betania" Evangelical Hospital, Naples, Italy, 4Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania L. Vanvitelli, Naples, Italy

OP 59Are Non-Injecting Drug Users at risk of HCV-infection? Data from the San Patrignano cohort

A. Boschini1, P. Piselli2, R. Poletti1, M. Begnini1, P. Ottogalli1, C. Cimaglia2, P. Parracino2, E. Girardi2

1Comunità San Patrignano (Rimini), 2INMI “L. Spallanzani” IRCCS, Rome

OP 60Real Life DAAs in a large cohort of people who use drugs with hepatitis C virus infection in Tor Vergata Hospital in Rome: adherence, efficacy and reinfections of a key population

T. Mulas, E. Teti, L. Foroghi, G. De Simone, L. Campogiani, L. Ferrari, C. Stingone, M. De Masi, L. Coppola, M. Compagno, M. Iannetta, L. Sarmati, M. Andreoni

Infectious Diseases Clinic, Tor Vergata Hospital, Rome, Italy

OP 61Effects of HCV eradication on liver function in haemophilic HIV/HCV co-infected patients

V. Castelli1, L. Taramasso1, F. Portunato2, G. Bozzi1, A. Gori1, A. Bandera1, A. Muscatello1, M.E. Mancuso3

1Infectious Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano, 2Infectious Diseases Unit, Azienda Ospedaliera Universitaria Federico II, Napoli, 3Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano

OP 62Virological patterns of HCV-patients with failure to second generation direct-acting antivirals

M. Starace1, M. Pisaturo1, C. Minichini1, S. De Pascalis1, M. Macera1, L. Occhiello1, A. Di Fraia1, L. Alessio2, V. Messina2, E. Claar3, T. Ascione4, A. Marrone5, V. Rosato3, I. Gentile6, V. Iovinella7, L. Fontanella8, G. D’Adamo9, R. Santoro10, G.B. Gaeta1, N. Coppola1

1Infectious Diseases Unit, Department of Mental and Physical Health and Preventive Medicine, University L. Vanvitelli, Naples, Italy, 2Infectious Diseases Unit, AO Caserta, Caserta, Italy, 3Internal Medicine Unit, Evangelical Hospital Villa Betania Naples, Italy, 4Internal Medicine Unit, University L. Vanvitelli, Marcianise (CE), Italy , 5Internal Medicine, University of Campania L. Vanvitelli, 6Infectious Diseases Unit, University Federico II, Naples, Italy, 7Internal Medicine Unit, P.O. S.Paolo - ASL Napoli 1, Naples, Italy, 8Internal Medicine Unit, AO Madonna del Buon Consiglio FATEBENEFRATELLI, Naples, Italy, 9Internal Medicine Unit, P.O. Umberto I Nocera Inferiore, 10Internal Medicine and Hepatology Unit, PO G. Da Procida-AOU- San Giovanni e Ruggi D'Aragona, University of Salerno

OP 63Advanced liver disease outcomes after Hepatitis C viral eradication according to Human Immunodeficiency Virus coinfection in PITER cohort

M.G. Quaranta1, L. Ferrigno1, M. Monti2, R. Filomia3, E. Biliotti4, A. Iannone5, G. Migliorino6, B. Coco7, F. Morisco8, M. Vinci9, R. D'Ambrosio10, L. Chemello11, M. Massari12, D. Ieluzzi13, F.P. Russo14, P. Blanc15, G. Verucchi16, M. Puoti17, M.G. Rumi18, F. Barbaro19, T.A. Santantonio20, A. Federico21, L. Chessa22, I. Gentile23, M. Zuin24, G. Parruti25, G. Morsica26, L.A. Kondili1 on behalf of PITER Collaborating Group*

1Center for Global Health, Istituto Superiore di Sanità, Rome, 2Interdepartmental Centre MASVE, University of Florence, Florence, 3Division of Clinical and Molecular Hepatology, University Hospital of Messina, Messina, 4Hepatology Unit, Department of Clinical Medicine, Sapienza University, Rome, 5Department of Emergency and Organ Transplantation, Gastroenterology Unit, University of Bari, Bari, 6Division of Infectious Diseases, San Gerardo Hospital, Monza, 7Hepatology and Liver Physiopathology Laboratory and Internal Medicine, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, 8Department of Clinical Medicine and Surgery, Federico II University, Naples, 9Departement of Hepatology and Gastroenterology, Niguarda Hospital, Milan, 10Pathophysiology and Transplantation Department, Gastroenterology and Hepatology, CRC AM e A Migliavacca Center for Liver Diseases, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, University of Milan, Milan, 11Department of Medicine, University Hospital of Padua, Padua, 12Infectious Diseases, Azienda Unità Sanitaria Locale – IRCCS di Reggio Emilia, Reggio Emilia, 13Clinical Unit of Gastroenterology, University Hospital of Verona, Verona, 14Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, 15Infectious Disease Unit, Santa Maria Annunziata Hospital, Florence, 16Department of Medical and Surgical Sciences, Clinic of Infectious Diseases and Microbiology Unit, Alma Mater Studiorum Bologna University, Bologna, 17Department of Infectious Disease, Niguarda Hospital, Milan, 18Hepatology Unit, San Giuseppe Hospital, University of Milan, Milan, 19Infectious and Tropical Diseases Unit, Azienda Ospedaliera di Padova, Padua, 20Infectious Diseases, Ospedali Riuniti, Foggia, 21Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, 22Liver Unit, University Hospital, Monserrato, Cagliari, 23Department of Clinical Medicine and Surgery, Federico II University, Naples, 24Department of Health Sciences, San Paolo Hospital, University of Milan, Milan, 25Infectious Disease Unit, Spirito Santo General Hospital, Pescara, 26Department of Infectious Diseases, San Raffaele Hospital, Milan, *available at www.progettopiter.it

OP 64The combination of accurate serological and virological HBV markers can help to predict the occurrence of HBV reactivation and to optimize prophylaxis duration in HBsAg-negative/anti-HBc-positive patients with oncohematological diseases

R. Salpini1, C. Cerva2, M. Alkhatib1, L. Piermatteo1, A. Battisti1, V. Malagnino2, L Fabeni1, M.L. Cantonetti3, W. Arcese3, F. Ceccherini-Silberstein1, C.F. Perno4, M. Andreoni2, L. Sarmati2, V. Svicher1

1Department of Experimental Medicine, Tor Vergata University, Rome, Italy, 2Clinical Infectious Disease, Department of System Medicine, Tor Vergata University, Rome, Italy, 3Department of Hematology, Stem Cell Transplant Unit, Tor Vergata University, Rome, Italy, 4Department of Oncology and Haemato-oncology, University of Milan

OP 65HBV and HDV infection in immigrants living in South Italy: epidemiological and virological characteristics

L. Onorato2, M. Pisaturo2,6, C. Sagnelli2,4, L. Alessio1,4, C. Monari1, L. Gualdieri5, C. Minichini2, G. Di Caprio1, M. Starace2, M. Caroprese1, L. Occhiello1, G. Scotto6, M. Macera2, E. Sagnelli2, N. Coppola1,2

1UOC di Malattie Infetttive, AORN Sant'Anna e San Sebastiano, Caserta, 2Sezione di Malattie Infettive, Dipartimento di Salute Mentale e Medicina Pubblica, Università della Campania Luigi Vanvitelli, Napoli, 3Centro di Accoglienza "La tenda di Abramo", Caserta, 4Centro Suore Missionarie della Carità, Napoli, 5Centro per la Tutela della Salute degli Immigrati, Napoli, 6Centro sociale ex canapificio Caserta, 7UOC di Malattie Infettive, Foggia

OP 66HEV infection as an emergent public health issue: is it a concern for Italian blood donors?

L. Colagrossi1, M. Mercuri2, A. Nava2, E. Matarazzo1, D. Campisi2, C.F. Perno1,2, D. Fanti2

1Residency in Microbiology and Virology, Università degli Studi di Milano, Milan; 2Chemical-clinical and Microbiological Analysis, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy

OP 67HIV SelfTesting: a survey of self-tests availability in Italian Pharmacies

M. Maffeo1,2, M.L. Cosmaro2, M. Kall3, S. Nash3

1Scuola di Specializzazione in Igiene e Medicina Preventiva - Università degli Studi Milano Statale, 2Fondazione Lega Italiana per la Lotta contro l’AIDS - LILA Milano, 3Public Health England

OP 68Testing MSM in cruising venues

D. Zagato1, A. Andolina1,L. Beltrami1, A. Bianchi1, A. Brambilla1, G. Calcagno1, D. Calzavara2, M. Carbonara2, D. Deserti2, A.J. Gallucci2, V. Gambini1, E. Garavaglia2, M.Gucciardi1, V. LaMonica1, S. Lolli1, L. Londei1, F. Maddaloni1, M. Manfredini1, G.M. Mattioli2, V. Nicotera1, D. Pennisi1, P. Peruggia1, A. Pezzotti1, M. Pierini1, C. Romero1, R. Rossotti1, A. Ruggeri2, P. Testoni1, L. Valpreda1, P. Vinti1, A.Ünlü1, M. Cernuschi1

1ASA Associazione Solidarietà AIDS, Milan, 2CIG-Arcigay, Milano

OP 69Behavioral aspects of MSM tested in community-based settings in 5 cities

M. Breveglieri1, P. Guarino2, A. Bignardi3, D. Pavia3, D. Calzavara4, M. Costacurta2, D. Deserti 4, F. Angeli 5, M. Marocco1, G. Corradini6

1Arcigay, Associazione LGBTI+ Italiana, 2Arcigay Padova, 3Arcigay Modena, 4Arcigay Milano, 5Arcigay Roma, 6Arcigay Verona

OP 70Pre-exposure prophylaxis in Modena: a wide spread of sexually transmitted infections among users attending the dedicated outpatient Clinic

C. Rogati1, C.G. Cuomo1, A. Raimondi1, M. Tutone1, E. Bacca1, B. Beghetto1, E. Roncaglia1, G. Nardini1, V. Borghi1, G. Guaraldi1, M. Coppini1, C. Mussini1

1Clinic of Infectious Diseases, University of Modena and Reggio Emilia, Modena, Italy, 2Clinic of Dermatology, University of Modena and Reggio Emilia, Modena, Italy

OP 71Prevalence and risk factors for HPV anal infection in PrEP users: implications for vaccination policy

R. Rossotti1, C. Baiguera1, A. Nava2, M. Merli1, D. Fanti2, S. Chiappetta1, M.C. Moioli1, L. Colagrossi2, L.G. Chianura1, D. Motta1, C.F. Perno2,3, M. Puoti1

1Department of Infectious Diseases, ASST Grande Ospedale Metropolitano Niguarda, Milan, 2Chemical-Clinical and Microbiological Analysis, ASST Grande Ospedale Metropolitano Niguarda, Milan, 3Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan

OP 72NEETagers for the prevention of HIV and AIDS

V. Corallino, M. Ramadori

Anlaids Umbria Onlus, Corciano (PG)

OP 73Clinical research integrated with narrative medicine to understand living and coping with HIV: TMC114FD1HTX4011 - DIAMANTE study

A. Antinori1, A. Vergori1, D. Ripamonti2, D. Valenti3, V. Esposito3, M.A. Carleo4, S. Rusconi5, E. Manzillo6, T. Pizzella6, G. Orofino7, G. Madeddu8, A. Cappuccio9, L. Reale9, M.G. Marini9, A. Uglietti10, R. Termini10, M. Portaro10, D. Mancusi10

1HIV/AIDS Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Roma, Italy, 2Infectious Diseases Unit, Papa Giovanni XXIII Hospital, Bergamo, Italy
3FROM Research Foundation, Papa Giovanni XXIII Hospital, Bergamo, Italy, 4Immunodeficiencies and Gender Infectious Diseases Unit, Department of Infectious Disease and Infectious Emergencies, Cotugno Hospital, Naples, Italy, 5Infectious Diseases Unit, DIBIC Luigi Sacco, University of Milan, Italy, 6A.O.R.N. Cotugno VIII Divisione di Malattie Infettive Napoli, Italy, 7Amedeo di Savoia Hospital Unit of Infectious Diseases Torino, Italy, 8University of Sassari, Department of Medical, Surgical and Experimental Sciences, Unit of Infectious Diseases Sassari Italy, 9Fondazione ISTUD, Milan, Italy, 10Medical Affairs Department, Infectious Diseases, Janssen-Cilag SpA, Cologno Monzese, Italy

OP 74Women and HIV in prison setting: a data up date from the Italian ROSE network

E. Rastrelli1, 2, R. Ranieri2,3, S. Marcellini2,4, E. Pontali2,5, R. Bergamaschi6, V. Esposito7, V. Rizzo7, A. Bascià8, M.R. Attianese9, A. Tartaglia10, F. Campanale11, L. Rapisarda12,V. Fiore13, T. Prestileo2,14, G. Leo2,15, M. Giuliano2,15, O. Mollaretti2,15, R. Marocco16, M. Pontolillo17, F. Vignale17, A. Lucarini18, G. Pugliese19, R. Giuliani3, A.M. Ialungo1,2, S. Dell’Isola1,2, L. Testa1,2, Lucania2,20, S. Babudieri2,13,G. Starnini1,2

1U.O.C. Medicina Protetta-Malattie Infettive, Ospedale Belcolle, Viterbo, 2SIMSPe (Società Italiana di Medicina e Sanità Penitenziaria), 3Azienda Ospedaliera Santi Paolo e Carlo Unità di Malattie Infettive, Università di Milano Unità di Malattie Infettive in Ambito Penitenziario, Milano, 4Casa Circondariale Rebibbia Femminile, Roma, 5Unità di Malattie Infettive, Ospedale Galliera, Genova, 6Casa Circondariale Pesaro, 7UOC Immunodeficienze e Malattie Infettive di Genere, Ospedale Cotugno, Napoli, 8Distretto Socio Sanitaria ASL Lecce, Poliambulatorio “Cittadella della Salute, 9ASL Salerno CC Salerno, 10Ambulatorio Malattie Infettive ASL Foggia, 11Specialistica Ambulatoriale ASL Bat, 12CC Catania, 13Unità di Malattie Infettive, Università di Sassari, Sassari, 14ARNAS, Ospedale Civico-Benefratelli Palermo, Palermo, 15Unità di Malattie Infettive, Ospedale Amedeo di Savoia, Torino Casa Circondariale "G. Panzera", 16Unità di Malattie Infettive, Università La Sapienza, Ospedale S. M., Latina, 17Clinica di Malattie Infettive, Dipartimento di Medicina ed Scienze dell'Invecchiamento, Università G. d'Annunzio, Chieti, 18Casa Circondariale di Perugia «Capanne», 19Casa Circondariale Avellino, 20Reggio Calabria ASP Reggio Calabria – Presidio I.P. RC “Panzera” e “Arghillà"

OP 75First-year experience of an HIV clinic-based stop-smoking service

V. Spagnuolo1,2, E. Lombardi2, A. Poli2, S. Bossolasco2, C. Raddato1, A. Castagna1,2, A. Lazzarin2, N. Gianotti2

1School of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, 2Division of Infectious Diseases, San Raffaele Scientific Institute, Milan

OP 76Psychiatric disturbances are common in PrEP users: an analysis of comorbidities and comedications in real life

R. Rossotti, C. Baiguera, M. Colaneri, M. Merli, S. Chiappetta, M.C. Moioli, L.G. Chianura, D. Motta, M. Puoti

Department of Infectious Diseases, ASST Grande Ospedale Metropolitano Niguarda

OP 77The HIV-1 provirus excised by CRISPR/Cas9 may be integrated back into the cell genome in presence of the viral integrase

M. Lai1,2, P. Quaranta1, F. Maggi1,3, M. Sgarbanti4, O. Turriziani7, G. Freer1, G. Antonelli7, J.L. Heeney2, M. Pistello1,3

1Retrovirus Center and Virology Section, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy, 2Laboratory of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom, 3Virology Unit, Pisa University Hospital, Pisa, Italy, 4National Institute of Health, Rome, Italy, 5Pharmacology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy, 6Hematology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy, 7Laboratory of Virology and Pasteur Institute-Cenci Bolognetti Foundation, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

OP 78Analysis of HIV latency establishment and maintenance in CD4 T cells stimulated with IL-15

G.M. Butta1,2, G. Bozzi3, G. Copaloni2, G. Gallo2, M. Crosti1, M. Mancino1, L. Taramasso3,4,5, A. Muscatello3, A. Gori3,4,5, R. De Francesco1,2, A. Bandera3,4,5, L. Manganaro1,3

1INGM-Istituto Nazionale di Genetica Molecolare, Virology, Milan, Italy, 2Università degli Studi di Milano, Department of Pharmacological and Biomolecular Sciences, Milan, 3Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Infectious Diseases Unit, Department of Internal Medicine, Milan, Italy, 4Centre for Multidisciplinary Research in Helath Science (MACH), 5Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

OP 79Phylogenetic analyses applied to the study of transmission variants and their evolution in a HIV-1 positive couple

A. Lai1ǂ, V. Giacomet2ǂ, A. Bergna1, G.V. Zuccotti2, G. Zehender1, M. Clerici3,4, D. Trabattoni1, C. Fenizia3

1Department of Biomedical and Clinical Sciences, University of Milan, Milan, 2Clinic of Pediatrics, ASST Fatebenefratelli-Sacco, Sacco Clinical Sciences Institute, Milan, 3Department of Pathophysiology and Transplantation, University of Milan, Milan, 4IRCCS Fondazione Don Carlo Gnocchi, Milan
ǂThe authors consider that the first two authors should be regarded as joint First Authors

OP 80Creation of an Italian HIV DNA Network for the validation and clinical use of HIV-1 DNA quantification assays

I. Vicenti1, F. Dragoni1, A. Giannini1, A. Callegaro2, G. Napolitano2, O. Turriziani3, D. Di Carlo3, S.Giambenedetto4,14, F. Lombardi4, S. Belmonti4, F. Ceccherini-Silberstein5, R. Scutari5, C. Alteri5,6, A. Lai7, A. Bergna7, S. Racca8, A. Ardemagni8, A. Casabianca9, C. Orlandi9, I. Bon10, A. Bertoldi10, P. Bagnarelli11, L. Di Sante11, I. Abbate12, G. Rozera12, M.R.Capobianchi12, S. Paolucci13, G. Campanini13, F. Saladini1, M. Zazzi1

1Department of Medical Biotechnologies, University of Siena, Siena, 2Microbiology and Virology Laboratory, ASST Papa Giovanni XXIII, Bergamo, 3Department of Molecular Medicine, Sapienza University of Rome, Rome, 4Department of Safety and Bioethics, Infectious Disease Section, Catholic University of Sacred Heart, Rome, 5Department of Experimental Medicine, University of Rome Tor Vergata, Rome, 6Department of Oncology and Hemato-oncology, University of Milan, Milan, 7Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Milan, 8Laboratory of Microbiology and Virology, IRCCS San Raffaele Scientific Institute, Milan, 9Department of Biomolecular Sciences, University of Urbino "Carlo Bo", Urbino, PU, 10Microbiology Section, Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Bologna, 11Virology Unit, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, 12Virology and Biosafety Laboratories Unit, National Institute for Infectious Diseases IRCCS L. Spallanzani, Rome, 13Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, 14Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC Infectious Disease Rome

OP 81Initial characterization of elements detected and quantified exclusively on the basis of LTR region by Aptima HIV-1 Quant Dx dual-target assay in plasma of HIV-positive patients

A. Amendola, G. Sberna, M.R. Capobianchi

National Institute for Infectious Diseases L. Spallanzani IRCCS, Rome, Italy

OP 82Stable total HIV-DNA after 1 year on switch to TAF-based regimens in real world data

C. Alteri1, A. Cozzi-Lepri2, R. Scutari3, Y. Bouba3, E.S. Cannizzo4, A. Tavelli5, M. Prato6, F. Bai4, A. Antinori7, A. d’Arminio Monforte4, F. Ceccherini-Silberstein3, G. Marchetti4
*on behalf of Icona and TAF-Icona Study Groups

1Dept. of Oncology and Hemato-Oncology, University of Milan, Milan, Italy, 2Centre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME) Institute for Global Health UCL, London, UK, 3Dept. of Experimental Medicine, University of Tor Vergata, Rome, Italy, 4Clinic of Infectious Diseases, Dept Health Sciences, University of Milan, ASST Santi Paolo e Carlo, Milan, Italy, 5Icona Foundation, Milan, Italy, 6Unit of Infectious Diseases, Santa Maria Annunziata Hospital, Florence, Italy, 7HIV/AIDS Clinical Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy

OP 83HIV-1 RNA and DNA mutational load in HTE patients with MDR virus: a tool for deciding OBR?

M.M. Santoro1, D. Armenia1,2, M.C. Bellocchi1, L. Carioti1, L. Galli3, A. Galli3, R. Scutari1, E. Salsi4, C. Mussini5, G. Sterrantino6, L. Calza7, B. Rossetti8, M. Zazzi9, A. Castagna3,10, on behalf of the PRESTIGIO Registry Study Group

1Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, 2Saint Camillus International University of Health Sciences, Rome, 3Clinic of Infectious Diseases, Istituto Scientifico San Raffaele, Milano, 4Azienda Ospedaliero-Universitaria Parma, 5Malattie Infettive, Policlinico di Modena, Modena, 6Department of Experimental and Clinical Medicine, University of Florence, 7Policlinico Sant`Orsola-Malpighi, Bologna, Italy, 8Azienda Ospedaliera-Universitaria Senese, Siena, Italy, 9University of Siena, Siena, Italy, 10Clinic of Infectious Diseases, Vita-Salute San Raffaele University, Milano

OP 84Viral tropism does not have any impact on CD4 recovery in acute HIV infection or AIDS

D. Vita, A. Giacomelli, L. Oreni, P. Tau, G.M. Bottani, V. Micheli, D. Mileto, L. Swenson, C. Brumme, M. Galli, S. Rusconi

Università degli studi di Milano, Milano

OP 85Antiviral effect of HIV1 tat/rev siRNA carried by nanoparticles in human CD4+ T cell line

F. Falasca1, F. Di Fonzo2, L. Chronopoulou2, I. Sciandra3, C. Palocci2, O. Turriziani1

1Department of Molecular Medicine, 2Department of Chemistry; Sapienza University of Roma, Italy, 3National Institute of Gastroenterology “S. de Bellis”, Research Hospital, Castellana Grotte, Italy

OP 86A real-life experience of vaccination strategies for HBV prevention in HIV patients

D. Tomasoni, L. Gazzola, D. Barbanotti, A. Tavelli, F. Bai, C. Tincati, S. Cianciola, K. Reister, P. Tognetti, A. De Bona, A. d'Arminio Monforte

Department of Health Sciences, Clinic of Infectious Diseases, ASST Santi Paolo e Carlo, University of Milan, Italy

OP 87A successful experience of an immunization program in HIV-positive adults

G. Chieffo, L. Maboni, M. Farinazzo, F. Franzetti, B. Menzaghi

ASST Valle Olona Ospedale di Busto Arsizio, Busto Arsizio (VA)

OP 88Plasma exchange and dolutegravir exposure. A case report

M. Mussa1,2, M. Sciarra1, A. Di Filippo1, R. Maserati3, A. Gaballo4, G. Dornini5, A. Maria Di Matteo3, P. Villani6

1Department of Internal Medicine – University of Pavia, Pavia, Italy, 2Unit of Infectious Diseases, SS Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy, 3Unit of Infectious Diseases, IRCCS San Matteo Hospital Foundation, Pavia, Italy, 4Unit of Nephrology, Dialysis and Transplantation, IRCCS San Matteo Hospital Foundation, Pavia, Italy, 5Immunohaematology and Transfusion Service and Cell Therapy Unit, IRCCS San Matteo Hospital Foundation, Pavia, Italy, 6Laboratory of Pharmacology and Clinical Pharmacokinetics, IRCCS San Matteo Hospital Foundation, Pavia, Italy

P 1A descriptive analysis of bloodstream infections in patients living with HIV in a large Italian center

A. Ciccullo1, A. Dusina1, B. Fiori2,3, A. Borghetti4, T. D’Inzeo2,3, M. Sanguinetti2,3, F. Pallavicini1,4, T. Spanu2,3, S. Di Giambenedetto1,4

1Section of Infectious Diseases, Department of Safety and Bioethics, Catholic University of the Sacred Heart, Rome, Italy, 2Istituto di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy, 3Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, 4UOC Malattie Infettive, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

P 2Amebic abscess of the spleen with severe sepsis and bronchial fistulisation in HIV+patient: case report

A. Franco1, F. Acconciagioco2, L. Aprea3, R. Filippelli2, R.M. Franco1, C. Palumbo2, T. Pizzella3, M. Sardo3, F. Simioli3 & E. Manzillo3

1UOSD Profilassi Post-Esposizione - AORN "Ospedali dei Colli" - Napoli, 2UOC Radiodiagnostica P.O. "Cotugno" - AORN "Ospedali dei Colli" - Napoli, 3UOC Immunodeficienze e Malattie dell'Emigrazione - AORN "Ospedali dei Colli" - Napoli

P 3Pneumocystis jirovecii Pneumonia in HIV-negative Patients, a Frequently Overlooked Problem: Case Series from a Large Italian Center

G. Bozzi1, V. Morena2, A.M. Peri1, L. Taramasso1,3, R. Ungaro1, P. Bono4, A. Grancini4, A. Maraschini4, C. Matinato4, A. Gori1,3, A. Bandera1,3

1Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy, 2III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Milano, Italy; Department of Biomedical and Clinical Sciences "Luigi Sacco", Università degli Studi di, Milano, Italy, 3Centre for Multidisciplinary Research in Health Science (MACH), Milan, Italy, 4Medical Laboratory of Clinical Chemistry and Microbiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

P 4Infection by Mycobacterium chimaera in two subjected undergoing cardiac surgery

F. Bulla1, V. Vespertini1, M. de Fazio2, T. Alcaro2, S. Nisticò2, L. Cosco1

1S.O.C. Malattie Infettive A.O. “Pugliese-Ciaccio” Catanzaro, 2S.O.C. Microbiologia A.O. “Pugliese-Ciaccio” Catanzaro

P 5A case of persistent relapsing abdominal mycobacterial infection requiring prolonged intravenous multi-drug treatment

M. Rossi, A. Soria, L. Bisi, F. Sabbatini, A. Cappelletti, P. Columpsi, S. Foresti, E. Colella, F. Iannuzzi, V. Cogliandro, G. Gustinetti, N. Squillace, P. Vitiello, N. Brianese, E. Pollastri, G. Migliorino, G. Lapadula

Unit of Infectious Diseases, San Gerardo Hospital, ASST Monza

P 6Comparison of immunoassays for quantitative serum HBsAg

G. Roncarati, S. Galli, A. Moroni, G. Furlini

Operative Unit of Clinical Microbiology, St. Orsola-Malpighi University Hospital, Bologna

P 7Cryptic HBV replication is frequently revealed in anti-HBc positive/HBsAg negative patients with HIV infection by applying a highly sensitive digital droplet PCR assay

R. Salpini1, V. Malagnino2, M. Alkhatib1, T. Mulas2, L. Piermatteo1, R. Scutari1, R. Chirichiello1, A. Bertoli1, K. Yu La Rosa1, M. Brugneti1, M. Ciotti3, M. Andreoni2, C.F. Perno4, F. Ceccherini-Silberstein1, L. Sarmati1, V. Svicher1

1Department of Experimental Medicine, Tor Vergata University, Rome, Italy, 2Clinical Infectious Disease, Department of System Medicine, Tor Vergata University, Rome, Italy, 3Microbiology and Virology Unit, Tor Vergata University Hospital, Rome, Italy, 4Department of Oncology and Haemato-oncology, University of Milan, Milan, Italy

P 8The multidisciplinary group for HPV related disease and STD in Azienda Ospedaliera Universitaria Pisana (AOUP) Cisanello. An opportunity for HIV and HIV at risk people

L. DelBono1, C. Menconi2, S. Verdenelli1, I. Marchetti3, V. Seccia4, C. Cambi4, P. Cuttano5, S. Panduri6, P. Mazzetti7, F. Maggi7, S. Esim8, A. Gallo9, A.G. Naccarato3, G.Naldini2, M. Pistello7, F. Menichetti1

1UO Malattie Infettive AOU Pisa, 2SOD Chirurgia Proctologica e Perineale AOUP, 3UO Anatomia Patologica 1 AOUP, 4ORL 1 Universitaria AOUP, 5UO Urologia Universitaria AOUP, 6UO Dermatologia Universitaria AOUP, 7Virologia AOUP, 8SOD Microbiologia batteriologica AOUP, 9UOC Igiene e Sanità Pubblica Azienda USL Toscana Nord Ovest

P 9Non-AIDS-defining cancers in a cohort of HIV positive patients

V. Barocci, S. Mazzanti, M. Di Pietrantonio, A. Polenta, P. Mantini, F. Pallotta, S. Olivieri, B. Candelaresi, L. Brescini, G. De Iaco, A. Fiorentini, O. Cirioni, A. Giacometti

Clinica Malattie Infettive e Tropicali, Parassitologia ed Epatiti croniche, Università Politecnica delle Marche, Ancona

P 10Case report on oncopathology in HIV-infected patients

Z. Akhmedjanova, D. Urunova, V. Barotova, M. Khasanova, D. Akhmedjanov

Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan, Tashkent; Tashkent Institute of Advanced Medical Studies, Tashkent;
AIDS Center. Tashkent; University of Toronto, Toronto

P 11Primitive NHL of bone in an HIV patient: case-report and review of literature

A. Amedeo, D. Testi, G. Ferraro, G. Verucchi , P. Viale , L. Calza

Infectious Disease Section, Alma Mater Studiorum University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

P 12Alexithymia and cancer-related mortality in Human Immunodeficiency Virus-Infected Patients: An Italian Multisite Prospective Cohort Study

F. Vadini1, F. Sozio1, G. Madeddu3, G. De Socio4, P. Maggi5, B.M. Celesia6, G. Nunnari7, F. Vichi8, P. DiStefano1, E.Tracanna1, E. Polilli2, A. Sciacca1, E. Mazzotta9, B. Zizi3, V. Lai3, C. Bartolozzi8, M.E. Flacco10, P. Bonfanti11, F. Santilli12, L. Manzoli13, G. Parruti1; CISAI Study Group

1Infectious Disease Unit, Pescara, 2Clinical Pathology Laboratory, Pescara, 3Department of Clinical and Experimental Medicine, Unit of Infectious Diseases University of Sassari, Sassari, 4Infectious Diseases Unit, Santa Maria Hospital, Perugia, 5Infectious Diseases Clinic, Policlinico Hospital of Bari, Bari, 6Division of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital Catania, Catania, 7Department of Clinical and Experimental Medicine, University of Messina, Messina, 8Infectious Diseases Unit, Santa Maria Annunziata Hospital, Bagno a Ripoli, Florence, 9Infectious Disease Unit, Teramo, 10Local Health Unit of Pescara, Pescara, 11Infectious Diseases Unit, A. Manzoni Hospital, Lecco, 12Department of Medicine and Aging and Center of Aging Science and Translational Medicine, University of Chieti, Chieti, 13Department of Medical Sciences, University of Ferrara

P 13Kaposi Sarcoma among AIDS-presenters in Modena: could it be a cluster?

E. Bacca1, M. Tutone1, G. Ciusa1, G. Cuomo1, A. Jary2, A.G. Marcelin2, V. Calvez2, V. Borghi1, C. Mussini1

1Clinica di Malattie Infettive e Tropicali, Azienda Ospedaliero Universitaria, Modena, Italy, 2Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Pitié-Salpêtrière hospital, departement of Virology, Paris, France

P 14Oral Human Papillomavirus (HPV) detection in the context of the multidisciplinary HPV group in Azienda Ospedaliero-Universitaria Pisana (AOUP): a screening opportunity for HIV+ and other at risk-patients

C. Cambi1, S. Verdenelli2, L. Del Bono2, C. Menconi3, P. Mazzetti6, I. Marchetti4, G. Cuttano, E. Balestri6, F. Maggi6, S. Esin8, A. Gallo7, A.G. Naccarato4, G. Naldini3, F. Menichetti2, M. Pistello6, V. Seccia1

1U.O. Otorinolaringoiatria Universitaria AOUP, 2U.O. Malattie Infettive AOUP, 3SOD Chirurgia Proctologica e Perineale AOUP, 4U.O. Anatomia Patologica 1 AOUP, 5U.O. Urologia Universitaria AOUP, 6Virologia AOUP, 7UOC Igiene e Sanità Pubblica Azienda USL Toscana Nord Ovest, 8SOD Microbiologia batteriologica AOUP

P 15HCC Recurrence 8 years post Liver-Transplant was linked to Hepatitis Delta Reactivation in a person living with HIV

G. Ciusa1, G. Dolci1, J. Milic1, M. Tutone1, C. Rogati1, M. Di Gaetano1, E. Franceschini1, N. De Maria2, F. Di Benedetto3, C. Mussini1, G. Guaraldi1

1Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Modena, Italy, 2Gastroenterology Unit, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy, 3Epato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy

P 16Epidemiological analysis from a newly established anal HPV screening ambulatory

M. Ridolfi, E.N. Cavallari, C. Borrazzo, L. Santinelli, G.P. Innocenti, L. Celani, G. De Girolamo, G. Ceccarelli, G. d'Ettorre, C.M. Mastroianni

Dipartimento di Sanità Pubblica e Malattie infettive, Sapienza Università di Roma, Rome

P 8The multidisciplinary group for HPV related disease and STD in Azienda Ospedaliera Universitaria Pisana (AOUP) Cisanello. An opportunity for HIV and HIV at risk people

L. DelBono1, C. Menconi2, S. Verdenelli1, I. Marchetti3, V. Seccia4, C. Cambi4, P. Cuttano5, S. Panduri6, P. Mazzetti7, F. Maggi7, S. Esim8, A. Gallo9, A.G. Naccarato3, G.Naldini2, M. Pistello7, F. Menichetti1

1UO Malattie Infettive AOU Pisa, 2SOD Chirurgia Proctologica e Perineale AOUP, 3UO Anatomia Patologica 1 AOUP, 4ORL 1 Universitaria AOUP, 5UO Urologia Universitaria AOUP, 6UO Dermatologia Universitaria AOUP, 7Virologia AOUP, 8SOD Microbiologia batteriologica AOUP, 9UOC Igiene e Sanità Pubblica Azienda USL Toscana Nord Ovest

P 9Non-AIDS-defining cancers in a cohort of HIV positive patients

V. Barocci, S. Mazzanti, M. Di Pietrantonio, A. Polenta, P. Mantini, F. Pallotta, S. Olivieri, B. Candelaresi, L. Brescini, G. De Iaco, A. Fiorentini, O. Cirioni, A. Giacometti

Clinica Malattie Infettive e Tropicali, Parassitologia ed Epatiti croniche, Università Politecnica delle Marche, Ancona

P 10Case report on oncopathology in HIV-infected patients

Z. Akhmedjanova, D. Urunova, V. Barotova, M. Khasanova, D. Akhmedjanov

Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan, Tashkent; Tashkent Institute of Advanced Medical Studies, Tashkent;
AIDS Center. Tashkent; University of Toronto, Toronto

P 11Primitive NHL of bone in an HIV patient: case-report and review of literature

A. Amedeo, D. Testi, G. Ferraro, G. Verucchi , P. Viale , L. Calza

Infectious Disease Section, Alma Mater Studiorum University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy

P 12Alexithymia and cancer-related mortality in Human Immunodeficiency Virus-Infected Patients: An Italian Multisite Prospective Cohort Study

F. Vadini1, F. Sozio1, G. Madeddu3, G. De Socio4, P. Maggi5, B.M. Celesia6, G. Nunnari7, F. Vichi8, P. DiStefano1, E.Tracanna1, E. Polilli2, A. Sciacca1, E. Mazzotta9, B. Zizi3, V. Lai3, C. Bartolozzi8, M.E. Flacco10, P. Bonfanti11, F. Santilli12, L. Manzoli13, G. Parruti1; CISAI Study Group

1Infectious Disease Unit, Pescara, 2Clinical Pathology Laboratory, Pescara, 3Department of Clinical and Experimental Medicine, Unit of Infectious Diseases University of Sassari, Sassari, 4Infectious Diseases Unit, Santa Maria Hospital, Perugia, 5Infectious Diseases Clinic, Policlinico Hospital of Bari, Bari, 6Division of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital Catania, Catania, 7Department of Clinical and Experimental Medicine, University of Messina, Messina, 8Infectious Diseases Unit, Santa Maria Annunziata Hospital, Bagno a Ripoli, Florence, 9Infectious Disease Unit, Teramo, 10Local Health Unit of Pescara, Pescara, 11Infectious Diseases Unit, A. Manzoni Hospital, Lecco, 12Department of Medicine and Aging and Center of Aging Science and Translational Medicine, University of Chieti, Chieti, 13Department of Medical Sciences, University of Ferrara

P 13Kaposi Sarcoma among AIDS-presenters in Modena: could it be a cluster?

E. Bacca1, M. Tutone1, G. Ciusa1, G. Cuomo1, A. Jary2, A.G. Marcelin2, V. Calvez2, V. Borghi1, C. Mussini1

1Clinica di Malattie Infettive e Tropicali, Azienda Ospedaliero Universitaria, Modena, Italy, 2Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Pitié-Salpêtrière hospital, departement of Virology, Paris, France

P 14Oral Human Papillomavirus (HPV) detection in the context of the multidisciplinary HPV group in Azienda Ospedaliero-Universitaria Pisana (AOUP): a screening opportunity for HIV+ and other at risk-patients

C. Cambi1, S. Verdenelli2, L. Del Bono2, C. Menconi3, P. Mazzetti6, I. Marchetti4, G. Cuttano, E. Balestri6, F. Maggi6, S. Esin8, A. Gallo7, A.G. Naccarato4, G. Naldini3, F. Menichetti2, M. Pistello6, V. Seccia1

1U.O. Otorinolaringoiatria Universitaria AOUP, 2U.O. Malattie Infettive AOUP, 3SOD Chirurgia Proctologica e Perineale AOUP, 4U.O. Anatomia Patologica 1 AOUP, 5U.O. Urologia Universitaria AOUP, 6Virologia AOUP, 7UOC Igiene e Sanità Pubblica Azienda USL Toscana Nord Ovest, 8SOD Microbiologia batteriologica AOUP

P 15HCC Recurrence 8 years post Liver-Transplant was linked to Hepatitis Delta Reactivation in a person living with HIV

G. Ciusa1, G. Dolci1, J. Milic1, M. Tutone1, C. Rogati1, M. Di Gaetano1, E. Franceschini1, N. De Maria2, F. Di Benedetto3, C. Mussini1, G. Guaraldi1

1Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Modena, Italy, 2Gastroenterology Unit, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy, 3Epato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy

P 16Epidemiological analysis from a newly established anal HPV screening ambulatory

M. Ridolfi, E.N. Cavallari, C. Borrazzo, L. Santinelli, G.P. Innocenti, L. Celani, G. De Girolamo, G. Ceccarelli, G. d'Ettorre, C.M. Mastroianni

Dipartimento di Sanità Pubblica e Malattie infettive, Sapienza Università di Roma, Rome

P 17Behavioural and awareness changes in a HIV prevention program based on women empowerment in Uganda

G. Micheli2, C. Seguiti2, F.V. Segala2, A. Pierantozzi3, F. Opira4, S. Di Murro2, A. D’Angelillo2, T. Tabu4, M. Chiuchiarelli2, D. Faliero2, B. Odong6, R. Lukwiya4, F.S. Aloi5, K. De Gaetano Donati1, A. Cingolani1,2 for 'Pe Atye Kena, no longer alone' study group

1Fondazione Policlinico A. Gemelli, IRCCS, Istituto di Clinica delle Malattie Infettive, Roma, 2Università Cattolica S. Cuore, Malattie Infettive, Roma, 3AIFA-Agenzia Italiana del farmaco, Roma, 4"Comboni Samaritans of Gulu” Health Center, Gulu, Uganda, 5Università Cattolica S. Cuore, Patologia Speciale Medica e Semeiotica Medica, Roma, 6Medical Teams International, Kitgum, Uganda

P 18Therapy burdens of Italian women living with HIV - Findings from the Positive Perspectives 2 Study

G.M. Corbelli1, S. Marcotullio2, P. Rizzini2, P. de los Rios3, A. Appiah4

1Plus Onlus, Bologna, Italy, 2ViiV Healthcare Verona VR, Italy, 3ViiV Healthcare Laval, Quebec, Canada, 4ViiV Healthcare Brentford, UK

P 19Transgender people and HIV

M. Formisano1, M. Errico2, A. Giacomelli3, D. Bernacchia4, G. Casella5, A. Tosano6, L. Brogonzoli7

1NPS Italia Onlus Vice President, Milan, 2NPS Italia Onlus President, Milan, 3III Infectious Diseases Unit, ASST-FBF-Sacco, Department of Biomedical and Clinical Sciences DIBIC Luigi Sacco, University of Milan, member of SIMIT, Milan, 4III Infectious Diseases Unit, ASST-FBF-Sacco, Department of Biomedical and Clinical Sciences DIBIC Luigi Sacco, University of Milan, member of SIMIT, Milan, 5NPS Italia Onlus Junior Researcher, Milan, 6NPS Italia Onlus Senior Researcher, Milan, 7NPS Italia Onlus Head Researcher, Milan

P 20HIV-positive transgender people in follow-up at an Italian single tertiary care hospital in Florence: a cross-sectional study

F. Lagi1, A. Botta1, S.T. Kiros1, M. Mazzetti2, A. Bartoloni1,2, G. Sterrantino1

1Department of Experimental and Clinical Medicine, University of Florence, Florence Italy, 2Infectious and Tropical Diseases Unit, Careggi University and Hospital, Florence, Italy

P 21HPV and bacterial vaginal infection impact on immune system in a cohort of HIV female population under suppressive ART

A. Carraro1, P. Nijhawan1, S. Vita2, R. Marocco2, L. Fondaco1, B. Kertusha1, L. Ansaldo1, V. Petrozza1,3, J. Cacciotti3, M. Renzelli2, C.M. Mastroianni1, M. Lichtner1,2

1Dept. Of Public health and Infection Disease, Sapienza, University of Rome, Italy, 2Infectious Disease Unit, SM Goretti Hospital, Latina, 3Pathological Anatomy, ICOT, Sapienza, University of Rome, Italy

P 22Qualitative analysis of significant clinical events in a cohort of patients after DAA treatment for chronic HCV infection after virological eradication

M. Mazzitelli, C. Costa, V. Pisani, G. Greco ,F. Serapide, V. Scaglione, R. Lionello, V. La Gamba, E.M. Trecarichi, C. Torti

Infectious and Tropical Disease Unit, “Magna Graecia University”, Catanzaro, Italy

P 23A fast track city micro-project to eradicate HCV infection in PLWHIV

F. Maggiolo, L. Comi, E. Di Filippo, R. Teocchi, D. Valenti, A. Callegaro, M. Rizzi

ASST Papa Giovanni XXIII, Bergamo

P 24A pilot intervention for HCV elimination among MSM in Rome: preliminary results

P. Piselli1, M. Giuliani2, M. Farinella3, C. Cimaglia1, A. Latini2, F. Carduccelli3, C. Ancona2, O. Bruzzi1, G. De Carli1, R. Esvan1, F. Gili1, M. Marra3, N. Orchi1, E. Piscitelli1, S. Pittalis1, A.R. Garbuglia1, A. Amendola1, S. Meschi1, S. Cicalini1, M. De Palo1, E. Grilli1, A. Antinori1, M.R. Capobianchi1, A. Cristaudo2, G. D’Offizi1, V. Puro1, E. Girardi1

1INMI “L. Spallanzani” IRCCS, Rome, 2Istituto Dermatologico San Gallicano, IRCCS, Rome, 3Circolo di Cultura Omosessuale “Mario Mieli”, Rome, Italy

P 25HCV eradication in people living with HIV in Sassari: the final countdown?

A. De Vito, N. Geremia, S. Malnati, V. Fiore, E. Princic, A.A. Muredda, M.A. Seazzu, I. Maida, S. Babudieri, G. Madeddu

Unit of Infectious Diseases, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy

P 26Glecaprevir/Pibrentasvir and Sofosbuvir/Velpatasvir/Voxilaprevir failure in a young man with genotype 1a congenital HCV infection: a case presentation

P. Columpsi*1, A.Soria1, E. Colella1, N. Squillace1, P. Vitiello1, M. Rossi1, G. Migliorino1, S. Paolucci2, F. Baldanti2,3, G. Lapadula1

1Unit of Infectious Diseases, San Gerardo Hospital, ASST Monza, 2Molecular Virology Unit, Microbiology and Virology Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico, San Matteo, Pavia, Italy, 3Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy

P 27Acute hepatitis C treatment with direct antiviral agents (DAAs) in patients with solid organ cancer

V. Bianco1, C. Dell'Isola1, F. Martucci1, B. Matteis1, G. Morelli1, P. Pierri1, R. Punzi2

1Infectious Disease Specialist, "D. Cotugno" hospital, Naples, Italy, 2Head of Infectious Disease, "D. Cotugno" hospital, Naples, Italy

P 28How to eliminate HCV in people who inject drugs? Preliminary results of a provincial multi-targeted approach involving three different settings: addictions services, prison, outreach mobile unit for active users

A. Soria1, E. Colella1, P. Columpsi1, E. Chiesa2, A. Cardia3, M. Bramani Araldi4, D. Leto3, G. Scaffidi4, S. Mancastroppa2, C. De Ferrari3, A. Caruso4, S. Marangon2, M. Pecoraro5, B. Tinghino5, G. Galimberti2, L. Vaira6, M. Grilli7, A. Cocchini7, C. Bregamo8, R. Galizzi8, G. Marconi9, G. Migliorino1, G. Lapadula1

1Unit of Infectious Diseases, San Gerardo Hospital, ASST Monza, 2Addiction service (SERD) of Monza, ASST Monza, 3Addiction service (SERD) of Limbiate, ASST Monza, 4Addiction service (SERD) of Carate Brianza, ASST Vimercate, 5Service of Alcohol disorders and new addictions (NOA) of Seregno, ASST Vimercate, 6Presidio Sanitario Penitenziario, ASST Monza, 7SERD Casa Circondariale Monza, 8Cooperativa Lotta Contro L’Emarginazione, 9UOS Raccordo della Rete Territoriale dei Servizi, ATS Brianza

P 29Innovative procedures for micro-elimination of HCV infection in persons who use drug (PWUD)

M. Pisaturo2,4, V. Messina1, A. Russo1,2, E. Parente3, G. Russo3, T. Raimondo3, A. Salzillo1, F. Simeone1, L. Onorato1, G. Di Caprio1, N. Coppola1,2,

1Infectious Diseases Unit, AORN Sant’Anna e San Sebastiano, Caserta, Italy; 2Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy, 3SerD Teano, Piedimonte Matese (Caserta); Italy, 4AORN Dei Colli, Ospedale Cotugno, Naples

P 30Short course therapy for chronic hepatitis C infection

G. Stroffolini, T. Lupia, G. Cariti, L. Boglione , G. Di Perri

Amedeo di Savoia Hospital, University of Torino, department of medical science

P 31DAA failure in HCV genotype 3: virological features and efficacy of re-treatment

M. Pisaturo1,4, L. Occhiello1, M. Starace1, C. Minichini1, A. Di Fraia1, S. De Pascalis2, M. Macera2, V. Messina3, V. Sangiovanni4, E. Claar5, D. Precone6, G. Stornaiuolo2, M.Stanzione2, I. Gentile8, G. Brancaccio2, S. Martini9, A. Masiello10, A. Salomone Megna11, C. Coppola12, A. Federico13, E. Sagnelli1, M. Persico14, A. Galeota Lanza15, A.Marrone16, G.B. Gaeta2, N. Coppola1,3

1Laboratory for the identification of prognostic factors of response to the treatment against infectious diseases, University of Campania "L. Vanvitelli", Napoli, Italy, 2Infectious Diseases and Viral Hepatitis, Department of Mental and Physical Health and Preventive Medicine, University of Campania "L. Vanvitelli", Napoli, Italy, 3Infectious Diseases Unit, A.O. S Anna e S Sebastiano Caserta, Italy, 4Third Infectious Diseases Unit, AORN deiColli, P.O. Cotugno, Naples, Italy, 5Internal Medicine Unit, Evangelical Hospital Villa Betania Naples, Italy, 6Internal Medicine Unit A.O Sarno, Sarno (SA) Campania L. Vanvitelli, &Infectious and Transplant Medicine, AORN Ospedali dei Colli- Monaldi Hospital, Naples, Italy, 7Gastroenterology Unit, AOU San Giovanni di Dio Ruggi d'Aragona, Salerno Italy, 8Infectious Diseases Unit, University Federico II, Naples, Italy, 9HIV Unit, University of Campania L.Vanvitelli, Naples, Italy, 10Infectious Diseases Unit, A.O S.G. Moscati, Avellino Italy, 11Infectious Diseases Unit, A. OG.Rummo, Benevento, 12Hepatology Unit, Gragnano Hospital, Gragnano, 13Internal Medicine and Hepatology Department of Clinical and Experimental Medicine, University of Campania "L. Vanvitelli", 14Internal Medicine and Hepatology Unit, PO G. Da Procida-AOU- San Giovanni e Ruggi D'Aragona,University of Salerno, 15Hepatology Unit,Cardarelli Hospital, Naples, Italy, 16Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, University of Campania "L. Vanvitelli"

P 32Therapy of Hepatitis C in Prison: Experience of Systematic Treatment Program in Rome

S. Rosati1, S. Lardo1, S. Marcellini2, G. Iannicelli1, P. Magrini3, C. Leonardi4, M. Zaccarelli1

1INMI L. Spallanzani, Rome (Italy), 2Infectivologist Doctor for Rebibbia Prison, 3Health Director ASL Frosinone, 4Health Director ASL RM 2 for Drug Addictions and Prisons

P 33Five years real-life experience with direct-acting antivirals for hepatitis C in a suburban setting in Rome: a retrospective analysis

L. Foroghi Biland, E. Teti, G. De Simone, T. Mulas, L. Campogiani, C. Stingone, L. Ferrari, M. De Masi, L. Coppola, M. Compagno, M. Iannetta, L. Sarmati, M. Andreoni

Infectious Diseases Clinic, Tor Vergata University Hospital, Rome, Italy

P 34Association Between Polymorphism in the Enhancer Gene and Hepatitis C Virus-induced Hepatocellular Cancer Risk

G. Greco1, V. Folliero2, V. Valastro1, D. D’orio1, F. Pinto1, S.A. Maiella1, M.V. Morone1, G. Franci3, L. Rinaldi4, M. Galdiero1

1Department of Experimental. Medicine, Section of Virology and Microbiology University of Campania “Luigi Vanvitelli”, Naples, Italy, 2Section of Microbiology and Virology, University Hospital Luigi Vanvitelli of Naples, Naples, Italy, 3Department of medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi (SA), Italy, 4Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy

P 35Genotyping and treatment issues with unusual 1e and 1g HCV subtypes from African subjects: report of two cases

C. Caudai1, P. Pierotti2, P. Galluzzi3, B. Rossetti3, P. Blanc2, M. Zazzi4

1Microbiology and Virology Unit, Siena University Hospital , Siena, Italy, 2Infectious Diseases Unit, S. Maria Annunziata Hospital, Florence , Italy, 3Infectious Diseases Unit, Siena University Hospital , Siena, Italy, 4Department of Medical Biotechnologies, University of Siena, Siena, Italy

P 36Feasibility and impact of HCV treatment in a HRS in Milan

G. Cocca1, V. Casigliani2, T. Sebastiani1, S. Mazzilli2,3, D. Bugatti1, G. Visi2, A. Stemat4, G. Arzilli2, P. Vigezzi1, C. Nicola1, P. Selva1, C. Catani1, L. Tavoschi2, R. Ranieri4

1Local Harm Reduction Service, San Paolo University Hospital, Milan, Italy Department of 2Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy, 3Scuola Normale Superiore, Pisa, 4Penitentiary Infectious Diseases Unit, San Paolo University Hospital, Milan, Italy

P 37An effective strategy to achieve HCV micro-elimination: HCV test and treatment into two Harm Reduction Services in Milan

T. Sebastiani1, S. Mazzilli2,3, G. Cocca1, V. Casigliani2, A. Stemat4, G. Arzilli2, P. Vigezzi1, G. Visi2, D. Bugatti1, C. Nicola1, P. Selva1, C. Catani1, L. Tavoschi2, R. Ranieri4

1Local Harm Reduction Servece, San Paolo University Hospital, Milan, Italy Department of, 2Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy, 3Scuola Normale Superiore, Pisa, 4Penitentiary Infectious Diseases Unit, San Paolo University Hospital, Milan, Italy

P 38Long follow up of monocyte-macrophage immuneactivation markers in HCV mono-infected patients undergoing DAA treatment

B. Kertusha1, P. Nijhawan1, L. Fondaco1, A. Curtolo1, C. Mascia1, I. Pozzetto1, R. Marocco2, A. Carraro1, F. Cogliati Dezza1, V. Rossi2, T. Tieghi2 , S. Vita2, C. Mastroianni1, M. Lichtner1,2

1Department of Public health and Infectious disease, Sapienza, University of Rome, 2Infectious Disease Unit, SM Goretti Hospital Latina

P 39EradichiamoCi: HCV micro-eradication project among 5 psychoactive substances user services using a DAA delivery strategy

P. Zuccala’1, R. Marocco1, G. Di Palma2, B. Kertusha2, L. Fondaco2, M. D’Achille1, V. Rossi1, A. Mecozzi3, T. Franci3, C. De Mei4, E. Mattacchioni4, W. Kebebe4, G. Papa4, G.Padula5, T. Danieli5, O. Coletta6, A. Parente6, F. Aiuti7, E. Montanari7, P. Spina8, C. Paiano8, A. Vetica1, M.P. Giardino5, M. Lichtner1,2

1UOC Infectious Disease, Ospedale S.Maria Goretti, Latina, 2Sapienza University of Rome, Polo Pontino, Latina, 3Hospital Farmacy, Ospedale S.Maria Goretti, Latina, 4Ser.D Latina, ASL Latina, Latina, 5Ser.D Terracina, ASL Latina, Terracina, 6Ser.D Formia, ASL Latina, Formia, 7Ser.D Priverno, ASL Latina, Priverno, 8Ser.D Aprilia, ASL Latina, Aprilia

P 40Effect of direct antiviral therapy against HCV on CD4+ T cell count in patients with HIV-HCV coinfection

B. Pinchera, A.R. Buonomo, R. Scotto, E. Zappulo, F. Borrelli, M.R. Cotugno, G. Di Filippo, I. Gentile

Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy

P 41HCV treatment in PWID: a linkage to care model in Cagliari

F. Pes1, C. Balestrieri1, M. Casale2, M. Buffa1, C. Guiso3, R. Altea4, O. Angioni5, L. Barca1, A. Cola2, S. Onali1, L. Chessa1,2

1Department of Medical Sciences and Public Health; Monserrato (CA) Italy, 2Liver Unit, University Hospital, Monserrato (CA) Italy, 3Ser.D. via Liguria, ATS, Cagliari, Italy , 4Ser.D. Via dei Valenziani, ATS, Cagliari, Italy, 5Ser.D., Quartu S.E. (CA), ATS, Italy

P 42Hepatitis A: has the outbreak ended?

E. Garlatti Costa1, P. Martelli2, R. Giacomello2, A. Berto3, A. Grembiale1, S. Grazioli1, R. De Rosa3, D. Villalta2, M. Tonizzo1

1Department of Internal Medicine, ASFO, Pordenone, 2Department of Immunology and Allergology, ASFO, Pordenone, 3Department of Microbiology and Virology, ASFO, Pordenone

P 43Re-treatment of HCV infection following failure to DAAs: data from the SCOLTA cohort

L.A. Nicolini1, B. Menzaghi2, P. Bonfanti3, F. Vichi4, A. Cascio5, A. Parisini6, G. V. De Socio7, K. Falasca8, A. Di Biagio1,9

1Infectious Diseases, Policlinico San Martino-IRCCS, Genova, Italy, 2Unit of Infectious Diseases, ASST della Valle Olona, Busto Arsizio Hospital, Busto Arsizio, Italy, 3Infectious Disease Unit, Ospedale A. Manzoni, Lecco, Italy, 4Infectious Diseases Unit, Santa Maria Annunziata Hospital, Bagno a Ripoli, Florence, Italy, 5Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy, 6Infectious Diseases Unit, SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy, 7Unit of Infectious Diseases, Department of Medicine 2, Azienda Ospedaliera di Perugia, Santa Maria Hospital, Perugia, 8Clinic of Infectious Diseases, Department of Medicine and Science of Aging, University 'G. d'Annunzio' Chieti-Pescara, Chieti, Italy, 9Department of Health Sciences (DISSAL), University of Genoa, Genova, Italy

P 44HEV in Southern Italy. Still a chimera?

C. Dell'Isola, B.M. Matteis, F. Martucci, G. Morelli, P. Pierri, V. Bianco, R. Punzi

Division of hepatic diseases- AORN "dei Colli" Monaldi-Cotugno-CTO, Naples

P 45Evaluation of early HCC occurrence rate and its risk factors in HCV patients treated with direct-acting antivirals

V. Valastro1, F. Foglia1, G. Greco1, D. D’orio1, F. Pinto1, S.A. Maiella1, M.V. Morone1, G. Franci2, M. Galdiero1

1Department of Experimental. Medicine, Section of Virology and Microbiology University of Campania “Luigi Vanvitelli”, Naples, Italy, 2Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi (SA), Italy

P 46Covid-19 in patients with HIV-1 infection: a single-centre experience in Northern Italy

L. Calza1, I. Bon2, V. Colangeli1, M. Borderi1, G. Beci1, F. Esposito1, L. Badia1, M. Tadolini1, M.C. Re2, P. Viale1

1Unit of Infectious Diseases and 2Unit of Microbiology, S.Orsola Hospital, University of Bologna, Bologna (Italy)

P 47A case of acute hepatitis C in a patient with HIV, occult HBV and SARS-CoV-2 co-infection

E. Garlatti Costa1, A. Grembiale1, C. Mazzaro2, A. Rosso1, A. Berto3, S. Grazioli1, O. Schioppa4, R. De Rosa3, M. Tonizzo1

1Department of Internal Medicine, Azienda Sanitaria Friuli Occidentale (ASFO), Pordenone, Italy, 2Department of Experimental Onco-Hematology, Centro Riferimento Oncologico (CRO), IRCCS, Aviano, Italy, 3Department of Microbiology and Virology, Azienda Sanitaria Friuli Occidentale (ASFO), Pordenone, Italy, 4Department of Oncology, Centro Riferimento Oncologico (CRO), IRCCS, Aviano, Italy

P 48SARS-CoV-2 infection in a highly-experienced person living with HIV

A. Ciccullo1,2, P. Del Giacomo1, A. Porfidia3, G. De Matteis3, R. Cianci3, F. De Vito3, A. Dusina1,2, A. Borghetti1, M. Tumbarello1,2, S. Di Giambenedetto1,2

1Fondazione Policlinico Universitario Agostino Gemelli IRCCS, UOC Malattie Infettive, Rome, Italy, 2Section of Infectious Diseases, Department of Safety and Bioethics, Catholic University of the Sacred Heart, Rome, Italy, 3Fondazione Policlinico Universitario Agostino Gemelli IRCCS, UOC Medicina Generale, Rome, Italy

P 49SARS-CoV-2 infection in a HIV+ patient on darunavir-based ART monotherapy: a case report

G.E. Recchia1, M. Ridolfi1, G. Siccardi1, F. Cogliati Dezza1, F. Alessi1, C. Pinacchio1, L. Santinelli1, G.P. Innocenti1, C. Scagnolari2, G. Ceccarelli1, G. d'Ettorre1, C. Mastroianni1

1Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy, 2Laboratory of Virology, Department of Molecular Medicine, affiliated to Istituto Pasteur Italia - Cenci Bolognetti Foundation, Sapienza University, Rome, Italy

P 50COVID-19 in people living with HIV (PLWH): clinical picture, viral clearance, cellular and antibody response in a case series of a reference HIV/AIDS center in a COVID Hospital in Rome

A. Mondi1, E. Cimini2, F. Colavita3, S. Cicalini1, C. Pinnetti1, G. Matusali3, R. Casetti2, A. Vergori1, V. Mazzotta1, R. Gagliardini1, V. Schininà4, E. Girardi5, V. Puro6, G Ippolito7, M. Capobianchi3, C. Castilletti3, C. Agrati2, A. Antinori1

1HIV/AIDS Department, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy, 2Cellular Immunology and Pharmacology Laboratory, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy, 3Laboratory of Virology, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy, 4Radiology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy, 5Clinical Epidemiology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy, 6AIDS Reference Center - National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy, 7Scientific Direction, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy

P 51Clinical course and viroimmunological impact of COVID-19 in HIV infected patients: a single-center report from Milan, Italy

A. Mastrangelo1, C. Muccini1, E. Bruzzesi1, M. Ranzenigo1, M. Chiurlo1, L. Galli2, A. Poli2, A. Castagna1,2, A. Lazzarin2, P. Cinque2
on behalf of the HIV-COVID OSR Study Group2 (E. Messina, A. Danise, M. Guffanti, R. dell’Acqua, S. Nozza, N. Gianotti, V. Spagnuolo, L. Fumagalli, H. Hamid, S. Bossolasco, G. Morsica, G. Gaiera, M. Cernuschi, M. Ripa, B. Castiglioni, C. Oltolini, D. Canetti, C. Tassan-Din, A. Andolina, P. Scarpellini, G. Tambussi, C. Uberti-Foppa)

1Vita-Salute San Raffaele University, Milan, 2Unit of Infectious Diseases, San Raffaele Hospital, Milan

P 52Management of emergency COVID-19 in prison, Monza experience

L.M. Vaira1, V. Costa1, M. Pitaniello2

1Medical Prison Unit, San Gerardo Hospital, ASST-Monza, Monza, Italy, 2Prison director of Monza

P 53Psychological impact and awareness of COVID-19 in young people with HIV

S. Bernardi1, E. Mozzo2, M. Di Pastena1, F. Leone3, C. Novello2, A. Oletto2, N. Cotugno4, P. Zangari4, P. Palma4, V. Santilli4, P. Palma4, O. Rampon5, C. Giaquinto2

1DPUO Immunoinfettivologia, Ospedale Pediatrico Bambino Gesù, Roma, 2Fondazione Penta, Padova, 3Università degli Studi di Roma, 4UOC Immunologia Clinica – DPUO, Ospedale Pediatrico Bambino Gesù, Roma, 5Department of Women's and Children's Health, University of Padova

P 54Review of lopinavir and darunavir use in SARS-CoV-2 and HIV co-infection: is it time to find another role and another actor?

E. Garlatti Costa1, R. Ranieri2, G. Basaglia3, R. De Rosa3, M. Tonizzo1

1Department of Internal Medicine, Azienda Sanitaria Friuli Occidentale, Pordenone, Italy, 2Infectious Diseases Service, Penitentiary Health System, San Paolo University Hospital, Milano, Italy, 3Department of Microbiology and Virology, Azienda Sanitaria Friuli Occidentale, Pordenone, Italy

P 55Seroprevalence of SARS-CoV2 antibodies in paediatric HIV patients

S. Bernardi, C. Casamento Tumeo, C. Concato, L. Coltella, S. Ranno, G. Linardos, L. Piccioni, C.F. Perno

Bambino Gesu' Children's Hospital Rome Italy

P 56Study of the types of the nervous system based on temperaments of HIV-infected patients

Z. Akhmedjanova1, D. Urunova2, Z. Kadyrova3

1Institute of Human Immunology and Genomics, Tashkent, 2Academy of Sciences of the Republic of Uzbekistan, Tashkent, 3Tashkent Institute for Advanced Medical Studies, Tashkent

P 57Persistent activation of CXCL13 axis in the Cerebrospinal fluid of People Living with HIV despite Central Nervous System Viral Suppression

M. Trunfio1, L. Mighetto2, S. Torresan1, C. Atzori3, S. Biffi1, M. Nigra2, D. Imperiale3, S. Bonora1, G. Di Perri1, A. Calcagno1

1Infectious Diseases unit, Amedeo di Savoia hospital, University of Torino, Torino, Italy, 2Diagnostic Laboratory unit, Maria Vittoria hospital, ASL Città di Torino, Torino, Italy, 3Neurology unit, Maria Vittoria hospital, ASL Città di Torino, Torino, Italy

P 58Limited health literacy (HL) ability and low awareness of HL difficulties in people living with HIV

V. Delle Donne1, N. Ciccarelli2, V. Massaroni, F. Lombardi1, C. Picarelli1, A. Borghetti, A. Emiliozzi1, A. Dusina1, A. Ciccullo1, D. Moschese1, G. Baldin1,5, D. Farinacci1, S. Di Giambenedetto1,4, M. Fabbiani3

1Università Cattolica del Sacro Cuore, Roma Italia, Istituto di Clinica Malattie Infettive, 2Dipartimento di Psicologia, Università Cattolica di Milano, 3UOC Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Senese, Siena, Italy, 4Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma Italia, UOC malattie infettive, 5Mater Olbia Hospital, Olbia, Italy

P 59Evolution of cognitive performance at a 2 years follow-up in a group of HIV-infected patients

V. Delle Donne1, N. Ciccarelli2, V. Massaroni1, F. Lombardi1, C. Picarelli1, A. Borghetti1, A. Emiliozzi1, A. Dusina1, A. Ciccullo1, D. Moschese1, G. Baldin1,5, D. Farinacci1, S. Di Giambenedetto1,4, M. Fabbiani3

1Università Cattolica del Sacro Cuore, Roma Italia, Istituto di Clinica Malattie Infettive, 2Dipartimento di Psicologia, Università Cattolica di Milano, 3UOC Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Senese, Siena, Italy, 4Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma Italia, UOC malattie infettive, 5Mater Olbia Hospital, Olbia, Italy

P 60Cerebrospinal fluid viral replication and burden of resistance in HIV-1-infected people with multidrug resistance treated with Ibalizumab

C. Muccini1, D. Canetti2, A. Bigoloni2, V. Spagnuolo1,2, L. Galli2, A. Poli2, M. Cernuschi2, P. Cinque2, E. Boeri3, M. Sampaolo3, A. Lazzarin2, A. Castagna1,2

1Vita-Salute San Raffaele University, Milan, Italy, 2Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy, 3Laboratory of Microbiology and Virology, IRCCS San Raffaele, Milan, Italy

P 61In Vitro Effect of Efavirenz on Cultured Primary Astrocytes: Analysis of Neurotoxicity and Matrix Metalloproteinase Inhibition

I. Pati1, T. Latronico1, S. Milella1, A. Fasano1, F. Mengoni2, M. Lichtner3, C.M. Mastroianni2, G.M. Liuzzi1

1Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari "A. Moro", Bari, Italy, 2Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy, 3Infectious Diseases Unit, Sapienza University, Latina, Italy

P 62Evaluation of Patient-Reported Outcomes (PROs) and cognitive performance in HIV naïve patients with advanced disease: results from the PRO-Advance study

A.C. Brita, C. Pinnetti, A. Vergori, G. Passavanti, P. Lorenzini, R. Gagliardini, R. Bellagamba, E. Grilli, A. Mondi, S. Grisetti, V. Mazzotta, F. Baldini, A. Giannetti, A. Antinori, S. Cicalini

National Institute for Infectious Diseases, IRCCS, L. Spallanzani - HIV/AIDS Unit, Rome, Italy

P 63Cerebrospinal Fluid anti-EBV Viral Capsid Antigen IgG Production associates with poorer Performance in Attention, Memory and Executive functions domains among People living with HIV

M. Trunfio1, A. Sacchi2, D. Vai3, F. Pittaluga2, A. Gaviraghi1, G. Guastamacchia3, G. Di Perri1, R. Cavallo2, S. Bonora1, A. Calcagno1

1Infectious Diseases unit, Amedeo di Savoia hospital, University of Torino, Torino, Italy, 2Microbiology and Virology unit, Città della Salute e della Scienza, University of Torino, Torino, Italy, 3Neurology unit, Maria Vittoria hospital, ASL Città di Torino, Torino, Italy

P 64Cryptococcal meningitis in a young woman HIV late presenter: a case report

V. Fortunato, A. Campagna, L. Iapicco, S. Madonia, R. Santoro, A. Spera, R. Verrioli, A. Masullo

AOU " San Giovanni di Dio E Ruggi D'Aragona" Salerno

P 65A multidisciplinary approach to imprint a successful long term adherence skill to Antiretroviral Therapy in naive patients: background and preliminary data of a pilot project of the GLAD group

G.C. Orofino1, M. Guastavigna1, M.C. Tettoni2, G. Mosso1, R. Interdonato1, C. Grassone2, R. Casciaro2, G. Cinnirella3, S. Bertini3, M.E. Bersia3, F. Busso4, S. Lupo4, S.Ferrero Merlino4

1Division A of Infectious Diseases, Amedeo di Savoia Hospital, Turin, Italy, 2Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy, 3Pharmacy Department, Amedeo di Savoia Hospital, Turin, Italy, 4Hospital Clinical Psychology, Amedeo di Savoia Hospital, Turin, Italy

P 66Switching Dolutegravir/Abacavir/Lamivudine single tablet regimen (STR) to a less-costly multi-tablet regimen of Dolutegravir+Abacavir/Lamivudine (generic) in the setting of virologic suppression: data at 48 weeks

S. Gardin, L. Sasset, S. Cavinato, E. Di Meco, A.M. Cattelan

Infectious Diseases Division, Azienda Ospedaliera Padova